Protein Info for Ac3H11_4326 in Acidovorax sp. GW101-3H11

Annotation: Survival protein SurA precursor (Peptidyl-prolyl cis-trans isomerase SurA) (EC 5.2.1.8)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 475 signal peptide" amino acids 1 to 24 (24 residues), see Phobius details PF13624: SurA_N_3" amino acids 65 to 185 (121 residues), 53.4 bits, see alignment E=8.1e-18 PF13623: SurA_N_2" amino acids 69 to 146 (78 residues), 29.7 bits, see alignment E=1.7e-10 PF09312: SurA_N" amino acids 70 to 186 (117 residues), 106.2 bits, see alignment E=3.7e-34 PF13616: Rotamase_3" amino acids 216 to 319 (104 residues), 50.9 bits, see alignment E=6.7e-17 amino acids 330 to 428 (99 residues), 75.5 bits, see alignment E=1.6e-24 PF00639: Rotamase" amino acids 223 to 317 (95 residues), 60.2 bits, see alignment E=1e-19 amino acids 335 to 425 (91 residues), 80.7 bits, see alignment E=4.1e-26 PF13145: Rotamase_2" amino acids 239 to 322 (84 residues), 27.1 bits, see alignment E=2e-09 amino acids 351 to 433 (83 residues), 35.6 bits, see alignment E=4.4e-12

Best Hits

Swiss-Prot: 59% identical to SURA_POLSJ: Chaperone SurA (surA) from Polaromonas sp. (strain JS666 / ATCC BAA-500)

KEGG orthology group: K03771, peptidyl-prolyl cis-trans isomerase SurA [EC: 5.2.1.8] (inferred from 72% identity to vei:Veis_4811)

Predicted SEED Role

"Survival protein SurA precursor (Peptidyl-prolyl cis-trans isomerase SurA) (EC 5.2.1.8)" in subsystem Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8)

Isozymes

Compare fitness of predicted isozymes for: 5.2.1.8

Use Curated BLAST to search for 5.2.1.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A165K3D1 at UniProt or InterPro

Protein Sequence (475 amino acids)

>Ac3H11_4326 Survival protein SurA precursor (Peptidyl-prolyl cis-trans isomerase SurA) (EC 5.2.1.8) (Acidovorax sp. GW101-3H11)
MNHRVFALALATLASMSMQGAAAQGLRPSGASPSGKSGLSAPSSPSARPPAAPSITLPAP
GAGAASRSADFIVAVVNSEPVTNYEVRSRLARAEAQLAKQGGAMPPRDLLAREVLERIIV
EKVQLQQARESGIKVDDMAVAQAEQGVARQNDMTVEQLYARLGRDGMSRERFREELRNQL
LQQRLREREVEARVKVTDLDVDQYLREEQKGTDPTAMEINLGHVLVLVPENASPVQVAER
QARAQRAADKVRAGEDFAAVAREFSDAAEGQRAGGLLGLRPADRYPELFVNSTLGLPVGS
IVGPVRSPAGFHVLKVVERVTAGMPATVVQNHARHILLRTGPQLSETAAATRLADYRRRV
LAGQADFAALAREHSQDGSAKDGGDLGWASPGRYVPEFEQALDTLKPGEISEPLVSRFGV
HLVQLLERREAKLTQREQREMARGAVREKKLDEAYATWAQELRGRAYVEYREPPQ