Protein Info for Ac3H11_4193 in Acidovorax sp. GW101-3H11

Annotation: DNA polymerase III alpha subunit (EC 2.7.7.7)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1078 TIGR00594: DNA polymerase III, alpha subunit" amino acids 11 to 1004 (994 residues), 492.2 bits, see alignment E=1.8e-151 PF02811: PHP" amino acids 12 to 122 (111 residues), 59.4 bits, see alignment E=1.4e-19 PF07733: DNA_pol3_alpha" amino acids 286 to 543 (258 residues), 289.5 bits, see alignment E=6.9e-90 PF17657: DNA_pol3_finger" amino acids 546 to 715 (170 residues), 182.5 bits, see alignment E=1e-57 PF14579: HHH_6" amino acids 788 to 890 (103 residues), 63 bits, see alignment E=6.3e-21 PF01336: tRNA_anti-codon" amino acids 969 to 1032 (64 residues), 27.6 bits, see alignment 5.6e-10

Best Hits

Swiss-Prot: 60% identical to DNAE2_BORBR: Error-prone DNA polymerase (dnaE2) from Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50)

KEGG orthology group: K14162, error-prone DNA polymerase [EC: 2.7.7.7] (inferred from 76% identity to aaa:Acav_2522)

Predicted SEED Role

"DNA polymerase III alpha subunit (EC 2.7.7.7)" in subsystem DNA-replication (EC 2.7.7.7)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.7

Use Curated BLAST to search for 2.7.7.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A165M4Y4 at UniProt or InterPro

Protein Sequence (1078 amino acids)

>Ac3H11_4193 DNA polymerase III alpha subunit (EC 2.7.7.7) (Acidovorax sp. GW101-3H11)
MEMTAFLPGYAELHCLSNFSFQRGASHPHELVERAAKLGYQALALTDECSVAGVVRAWKA
AQSTGLHFIVGSEFLWGDLRLVALARDAEGWGNLCEFISAARRAAPKGQYHVGPASPWHL
LQGCELLLAPCRKRFDATDLIAIEAYLLRAKACFGSDFDGHIWLAAELHLAPDDGLWLAT
LQRVGAQLGLPLVAAGDVHMHARSRKPLQDVITAVRLGCSVAECGFALQPNAERHLRQRV
RLAGIYPPDLLAATLTVAGRCTFQLDEIKYQYPRETVPEGMTPAQALAWLVQTGVEGEYP
QGAPQRVLDQIRKELELIAHCQYEMYFLTVHDIVRYARSQKILCQGRGSAANSVVCYMLG
ITAVPPENTHLLFERFISKERKEPPDIDVDFEHDRREEVIQYIYDKYGRDRAAIAAVVTS
YRTRSALRDVGKALGVAPALVDAFAKDHHWFDETFAADRLQELAQAVGAALHRHTATLWL
ELAADLQGFPRHLSQHVGGFVLTQGKLTRLVPVEPASMDNRSVIQWDKDDLDDMGLLKVD
VLALGMLSALRRCLQLRAALRGEHWSLKNIPHEDPATYDMICAADTVGVFQIESRAQMSM
LPRLRPREFYDLVVEVAIVRPGPIQGGMVHPYLKARERRRQGLPLELEKPELEEALERTL
GVPIFQEQVMQIAMIAAGFTPGMADDLRRSMAAWKRKGGVHRFEEPLKQGMEANGYPAEF
ADRIFQQMLGFGEYGFPESHAHSFALLAYASSWLKCHEPACFLAALLNSLPMGFYTASQL
VQDARRHGVRVLPIDVSHSDHDCTLEGPAEHLLPAKGLPRPQQPQPAVRLGLCLVGSLGK
GAADRLVLARATSPFSTTEDLALRAQLSQQDVQALAAADALASLSGHRRQQMWDAAAQHS
APALLRDVPVLEAPLALPAAPEGEEILFDYAATGLTLRRHPLALLRPRLARWRLQTALQL
VATPHGRQVRACGIVTVRQRPGTAKGTMFVTLEDETGPVNVIVWPAMVDRWRNALLRSQL
LAVEGLWQCSVPEGSSAHSXPSGQAPAVVRHLVAQRFKDLTPLLGRMAQALQGSRDFH