Protein Info for Ac3H11_4179 in Acidovorax sp. GW101-3H11
Annotation: Gamma-aminobutyrate:alpha-ketoglutarate aminotransferase (EC 2.6.1.19)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 66% identical to DAVT_PSEPK: 5-aminovalerate aminotransferase DavT (davT) from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)
KEGG orthology group: K07250, 4-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate transaminase [EC: 2.6.1.19 2.6.1.22] (inferred from 80% identity to pol:Bpro_2912)MetaCyc: 66% identical to 4-aminobutyrate transaminase subunit (Pseudomonas fluorescens)
4-aminobutyrate transaminase. [EC: 2.6.1.19]
Predicted SEED Role
"Gamma-aminobutyrate:alpha-ketoglutarate aminotransferase (EC 2.6.1.19)" (EC 2.6.1.19)
MetaCyc Pathways
- 4-aminobutanoate degradation II (2/2 steps found)
- 4-aminobutanoate degradation III (2/2 steps found)
- L-valine degradation I (6/8 steps found)
- superpathway of 4-aminobutanoate degradation (2/3 steps found)
- 4-aminobutanoate degradation I (1/2 steps found)
- GABA shunt I (2/4 steps found)
- GABA shunt II (2/4 steps found)
- 4-aminobutanoate degradation V (3/7 steps found)
- superpathway of L-arginine and L-ornithine degradation (6/13 steps found)
- superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (4/11 steps found)
- nicotine degradation I (pyridine pathway) (5/17 steps found)
KEGG Metabolic Maps
- Alanine and aspartate metabolism
- Butanoate metabolism
- Glutamate metabolism
- Propanoate metabolism
- Valine, leucine and isoleucine degradation
- beta-Alanine metabolism
Isozymes
No predicted isozymesUse Curated BLAST to search for 2.6.1.19 or 2.6.1.22
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A165M4U1 at UniProt or InterPro
Protein Sequence (459 amino acids)
>Ac3H11_4179 Gamma-aminobutyrate:alpha-ketoglutarate aminotransferase (EC 2.6.1.19) (Acidovorax sp. GW101-3H11) MDGVWRDFQNPPHSFISSSTTTPTTMQQDRHFTNAALLTRRHAAVARGVGQAHDLFIQKA RNAELWDVEGRRFIDFAGGIAVLNTGHLHAGVIAAVKAQLDLYTHTCFQVVAYEPYVEVC ERLNTLAPGAFAKKSLLLTTGAEAVENAIKIARAYTKRPGVIAFTGGYHGRTNLTLGLTG KVAPYKIGFGPFPGETYHALFPNALHGVSVEQALHSVELIFKNDIEPERVAAFIVEPVQG EGGFYVAPPEFISGLKTLADRYGILLIADEVQTGAGRTGTWFASEQWPVAPDLITTAKSL AGGFPLAGVVGRADVMDAPAPGGLGGTYAGSPVACAASLAVIEAFAQEKLLARSQDMGAL LVRSLKDLAARIPAIGDVRGLGAMVAIELFENGDLSRPDAALTKQVVAEAARRGLILLSC GTHGNVIRILVPLTASDELLHEGLAILADSLEAVATAAN