Protein Info for Ac3H11_4074 in Acidovorax sp. GW101-3H11

Annotation: Feruloyl-CoA synthetase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 599 PF00501: AMP-binding" amino acids 46 to 426 (381 residues), 169.4 bits, see alignment E=5.5e-54

Best Hits

KEGG orthology group: K12508, feruloyl-CoA synthase [EC: 6.2.1.34] (inferred from 75% identity to vap:Vapar_0071)

Predicted SEED Role

No annotation

MetaCyc Pathways

Isozymes

Compare fitness of predicted isozymes for: 6.2.1.34

Use Curated BLAST to search for 6.2.1.34

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A165M073 at UniProt or InterPro

Protein Sequence (599 amino acids)

>Ac3H11_4074 Feruloyl-CoA synthetase (Acidovorax sp. GW101-3H11)
MHPVFLDDEDQIAPPRTLRRSLDDGSFTLRSPEALRPYARCVGEWLERWAKETPDTLALA
ERDASGEDWRGLSYAQLRRDVGAVAQSLLDLKLPAGRPIAILSDNAVDHAVLMLAAMHVG
ITPCSMSSAYARSQDPSRLHSMLAVLEPSLVYASDAQVYAPALAGYGGEVVKVFSRHADR
CAGALAFEQLQRGQETSAVRQAFEALDADGHAKYLLTSGSTGRPKVVINTHRMLCANQQM
MAQTWRFMAHEKPVLVDWLPWSHTFGGNHNLNMVLCHGGTLYIDEGRPMPGLIDKTVRNL
RDVQPTMLFNVPRGFDMLLPFLEADEALAAQVLARVRLAFYAAAALAPSTWQRLEALAHR
VRPARPLWLTTSWGSTETAPAVTTAHWRLEGAGCIGAPLPGLELKLVPNGGKLEMRVKGV
SVFAGYRNAPSETAAAFDSEGFYRIGDAGYLADAERPERGVVFNGRVAEDFKLSSGSWVS
VGTLRVELVSQLAPLVQDIVLTGHNRDEVGMLVFPSAAGVADTGRLEAALRALMRARRSA
GAGSSQCPTRALVMREPPDADAGEITDKGYINQGAVLSRRAAAVAALYAEPAAAGVITG