Protein Info for Ac3H11_4021 in Acidovorax sp. GW101-3H11
Annotation: Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K00525, ribonucleoside-diphosphate reductase alpha chain [EC: 1.17.4.1] (inferred from 86% identity to aav:Aave_0864)Predicted SEED Role
"Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)" in subsystem Ribonucleotide reduction (EC 1.17.4.1)
MetaCyc Pathways
- superpathway of histidine, purine, and pyrimidine biosynthesis (42/46 steps found)
- superpathway of purine nucleotides de novo biosynthesis I (21/21 steps found)
- superpathway of purine nucleotides de novo biosynthesis II (23/26 steps found)
- superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (17/18 steps found)
- pyrimidine deoxyribonucleotides de novo biosynthesis I (9/9 steps found)
- superpathway of purine nucleotide salvage (12/14 steps found)
- superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli) (12/14 steps found)
- superpathway of guanosine nucleotides de novo biosynthesis I (6/6 steps found)
- pyrimidine deoxyribonucleotides de novo biosynthesis III (8/9 steps found)
- superpathway of adenosine nucleotides de novo biosynthesis I (5/5 steps found)
- superpathway of guanosine nucleotides de novo biosynthesis II (7/8 steps found)
- pyrimidine deoxyribonucleotides de novo biosynthesis IV (6/7 steps found)
- superpathway of adenosine nucleotides de novo biosynthesis II (6/7 steps found)
- adenosine deoxyribonucleotides de novo biosynthesis I (2/2 steps found)
- guanosine deoxyribonucleotides de novo biosynthesis I (2/2 steps found)
- pyrimidine deoxyribonucleotides biosynthesis from CTP (6/8 steps found)
- adenosine deoxyribonucleotides de novo biosynthesis II (3/4 steps found)
- guanosine deoxyribonucleotides de novo biosynthesis II (3/4 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 1.17.4.1
Use Curated BLAST to search for 1.17.4.1
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A165LZ23 at UniProt or InterPro
Protein Sequence (981 amino acids)
>Ac3H11_4021 Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1) (Acidovorax sp. GW101-3H11) MQAALNTPSTAQPGPADSNESQATPAATASNEFAHHQIIRRNGAVVPFEPQKIAVAMMKA FLAVHGTQGAASASVREVVDTLTHNVTRALVRSRPGGGTFHIEDVQDHVELGLMRGGHHE VARAYVLYRERRTQERARQSEQQAPVASAPLLHVLDGDARIALDLGRLQALIESACVNLG ADVKADPIVAETMRNLYDGVPMDEVYKASILAARTLIEKDPDYTYATARLLLHTIVREVL GKEVTQAEMGQAYLEYFPQFIKKGVDNELLDERLLTYNLQRLGAALKADRDLKFDYLGLQ TLYDRYFLHVKKTRIELPQAFFMRVAMGLALNETDREARAIEFYEVLSSFDFMSSTPTLF NSGTLRSQLSSCYLTTVPDDLDGIYESIKENALLSKFAGGLGNDWTRVRALGSHIKGTNG ESQGVVPFLKVVNDTAVAVNQGGKRKGAVCTYLETWHLDIEEFLELRKNTGDDRRRTHDM NTANWIPDLFMRRVMEKGTWTLFSPSNVPDLHDLFGADFEKAYVAYEEKAARGEIKPAKT VQATDLWRKMLTMLFETGHPWITYKDACNVRSPQQHAGVVHSSNLCTEITLNTSDTETAV CNLGSVNLLQHLKDGQIDHDKLKKTITVAMRMLDNVIDINYYAVTKARDSNLRHRPVGLG VMAFQDSLYELRIPYASQQAVEFADKSMEAICYYAYWASTELAKERGKYSSYKGSLWDRG ILPFDTLDMLSQARGGYVEVDRSSTLDWDALRKKIAQDGMRNSNCVAIAPTATISNIIGV DASIEPSFGNLSVKSNLSGEFTVINGGLVRDLKRLGLWDDVMIMDLKHFKGSLHPIDRVP QDIKALYSTAFEVEPQWLVEAASRRQKWIDQAQSLNIYMAGASGKKLDDTYKLAWIRGLK TTYYLRTQSATHVEMSTVNTRQLNAVSSGNDGGASAASAPAQAQPSALETAAAAAAAQSA AVPATDVKFCAIDDPGCEACQ