Protein Info for Ac3H11_3994 in Acidovorax sp. GW101-3H11

Annotation: IMP cyclohydrolase (EC 3.5.4.10) / Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00355: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase
  • amino acids 2 to 533 (532 residues), 704.9 bits, E=3.5e-216
• PF02142: MGS
  • amino acids 12 to 126 (115 residues), 96.7 bits, E=7.4e-32
• PF01808: AICARFT_IMPCHas
  • amino acids 132 to 463 (332 residues), 398.7 bits, E=2.1e-123

Best Hits

KEGG orthology group: K00602, phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC: 2.1.2.3 3.5.4.10] (inferred from 92% identity to aav:Aave_0896)

Predicted SEED Role

"IMP cyclohydrolase (EC 3.5.4.10) / Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3)" in subsystem De Novo Purine Biosynthesis (EC 2.1.2.3, EC 3.5.4.10)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (42/46 steps found)
• superpathway of purine nucleotides de novo biosynthesis I (21/21 steps found)
• superpathway of purine nucleotides de novo biosynthesis II (23/26 steps found)
• inosine-5'-phosphate biosynthesis II (5/5 steps found)
• inosine-5'-phosphate biosynthesis I (5/6 steps found)
• inosine-5'-phosphate biosynthesis III (4/6 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from histidine and purine
• Biosynthesis of plant hormones
• One carbon pool by folate
• Purine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.1.2.3 or 3.5.4.10

Sequence Analysis Tools

See A0A165LYI7 at UniProt or InterPro

Protein Sequence (533 amino acids)

>Ac3H11_3994 IMP cyclohydrolase (EC 3.5.4.10) / Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (Acidovorax sp. GW101-3H11)
MNALLSVSDKTGIVEFAQALHTLGIKLLSTGGTAKLLADKGLPVTEVAEVTQFPEMLDGR
VKTLHPKVHGGLLARRELPEHMAALKQHGIDTIDLLVVNLYPFEATVAKAGCTLADAIEN
IDIGGPAMVRSAAKNWKDVGVITSADQYEAVLAELKANGKLSDKLRFALSVAAFNRIAQY
DGAISDYLSSVTFEEEKLSETYVPTRTQFPGQSNGIFTKVQDLRYGENSHQQAALYRDLH
PAPGSLVTGVQLQGKELSYNNIADADAAWECVKSFDAAACVIVKHANPCGVAVGLDALSA
YSKAFQTDPTSAFGGIIAFNRVVDGPAAQQVSKQFVEVLMAPDFTAEALEIFKAKANVRL
LKIALPTHGGKTDWERGRNAMDAKRIGSGLLLQTADNHELSLIDLKVVTQKQPTLEEMED
LLFAWKVAKYVKSNAIVFCKGGMTMGVGAGQMSRLDSARIASIKAGHANLSLQGTVVASD
AFFPFRDGLDVVVDAGATCVIQPGGSMRDNEVIDAANERGVAMVFSGVRHFRH