Protein Info for Ac3H11_3644 in Acidovorax sp. GW101-3H11

Annotation: Pole remodelling regulatory diguanylate cyclase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 376 PF00072: Response_reg" amino acids 21 to 132 (112 residues), 92.8 bits, see alignment E=2.3e-30 PF13487: HD_5" amino acids 175 to 353 (179 residues), 108.8 bits, see alignment E=4e-35 PF01966: HD" amino acids 186 to 322 (137 residues), 68.7 bits, see alignment E=8.1e-23

Best Hits

Swiss-Prot: 52% identical to CDPD2_PSEAE: Cyclic di-GMP phosphodiesterase PA4781 (PA4781) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K07814, putative two-component system response regulator (inferred from 86% identity to dia:Dtpsy_0962)

Predicted SEED Role

"Pole remodelling regulatory diguanylate cyclase" in subsystem ZZ gjo need homes

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A165J4G0 at UniProt or InterPro

Protein Sequence (376 amino acids)

>Ac3H11_3644 Pole remodelling regulatory diguanylate cyclase (Acidovorax sp. GW101-3H11)
MDNAPFAASQATLVDKPIATVLVVDDTPENLTLMGSLLREHYLVKVANHGEKAIKIAQSG
TPPDLILLDIMMPEVDGYEVCRRLKAAAATRDIPVIFLTARSDPDDERMGLALGAVDYIT
KPISPPILLARVNTHLALKATADFLRDKSSYLEREVAMRTLEVQAIQDVTIMAMTSLAET
RDNETGNHIRRTQLYMKTLAERLRHHPRFEHVLNDRMIELLYKSAPLHDIGKIGIPDSIL
LKPGKLTVEEFEVMKTHTTLGRNAIEEAERRLGMRVAFLSVSKEIAYSHQEKWDGTGYPQ
GLAGDAIPVSARLMALADVYDALISKRVYKPAFSHDQACSTIVRGKGTHFDPDMVDAFVD
IAEDFRSIAQKYPDPV