Protein Info for Ac3H11_3618 in Acidovorax sp. GW101-3H11
Annotation: Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 64% identical to MDTB_CROS8: Multidrug resistance protein MdtB (mdtB) from Cronobacter sakazakii (strain ATCC BAA-894)
KEGG orthology group: K07788, RND superfamily, multidrug transport protein MdtB (inferred from 85% identity to adn:Alide_3060)Predicted SEED Role
"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A165J3R7 at UniProt or InterPro
Protein Sequence (1036 amino acids)
>Ac3H11_3618 Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA (Acidovorax sp. GW101-3H11) MNLSRLFILRPIATALLMVAILIAGLMAYRLLPTSALPEVDYPTIQVTTLYPGASPDVMT SNVTAPLERQFGQMPGLSQMSSTSSGGASVITLRFALDMALDVAEQQVQAAINAGSNLLP SDLPMPPLYSKVNPADAPILTLAITSPSLPVIRVNDLVENRLAPKLSQVQGVGLVAIAGG RRPAVRIQANPTALAQLGLTLEDVRTSIAAANVKQAKGGFDGPARASTIDANDQLQSAAE YRDLIIAFKNGAPVRLKDVADTVDDAENTRLAAWAGTADTGAKPGVILNIRRQPGANVID TVDRIKALLPQLQSTLPASLDVQVLTDRTVTVRASVRDMQLELGLAVVLVVAVIFVFLRS PSATLIPSVAVPLSLIGTCGVMYLAGFSINNLTLMALTISTGFVVDDAIVMIENIARYVE EGEAPLAAALKGSQQIGFTIISLTISLIAVLIPLLFMGDVVGRLFHEFAITLAVSILISA VVSLTLTPMLCARLLRHTPEESHGRLYQATGQFFDRTIAGYGRMLAWVLDRRGWTWLVFL ATLALTVVLYLFIPKGFFPVQDTGTLQATTEADQSISFAGMAARQQAVAERLLEDPAVRS VSSFIGVDGANTTLNTGRLLIDLQPHAERDKASVVQQRLAERVQNLPGIRLFIQPVQDLT IEDRVARTQYQWLLSSPDMLQLTTSTTELLRRLRALPELTDVASDLQDQGRQAYVQIDRA QASRLGVTVAGIDAALYNAFGQRLISTIFTQSNQYRVVLEVAPQFKVGPEALQSIYVPSS AGAPVPLSSVARIEERNMPLVVNHVGQLPAATISFNTAPGVSLGNAVVAIEREKAAVQAE GLLPLSVETSFQGAALAFQASLSNTLLLILAAVVTMYIVLGVLYESTVHPVTILSTLPSA GVGALLALMAAQLDLDIIAIIGIVLLIGIVKKNAIMMIDFALEAQRDEGLSARDAIYQAC LLRFRPILMTTLAALLGALPMMLGTGVGSELRHPLGVTMVGGLILSQLLTLFTTPVIYLT FEGWVQRWRGRRGVGA