Protein Info for Ac3H11_3452 in Acidovorax sp. GW101-3H11

Annotation: Ribose-phosphate pyrophosphokinase (EC 2.7.6.1)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 324 TIGR01251: ribose-phosphate diphosphokinase" amino acids 9 to 318 (310 residues), 416.5 bits, see alignment E=2.6e-129 PF13793: Pribosyltran_N" amino acids 9 to 125 (117 residues), 174.8 bits, see alignment E=7.8e-56 PF00156: Pribosyltran" amino acids 159 to 253 (95 residues), 76 bits, see alignment E=3.1e-25 PF14572: Pribosyl_synth" amino acids 207 to 317 (111 residues), 104.1 bits, see alignment E=1.4e-33

Best Hits

Swiss-Prot: 76% identical to KPRS_RALSO: Ribose-phosphate pyrophosphokinase (prs) from Ralstonia solanacearum (strain GMI1000)

KEGG orthology group: K00948, ribose-phosphate pyrophosphokinase [EC: 2.7.6.1] (inferred from 96% identity to vei:Veis_0951)

MetaCyc: 65% identical to ribose-phosphate diphosphokinase (Escherichia coli K-12 substr. MG1655)
Ribose-phosphate diphosphokinase. [EC: 2.7.6.1]

Predicted SEED Role

"Ribose-phosphate pyrophosphokinase (EC 2.7.6.1)" in subsystem De Novo Purine Biosynthesis or Pentose phosphate pathway (EC 2.7.6.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.6.1

Use Curated BLAST to search for 2.7.6.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A165IZ00 at UniProt or InterPro

Protein Sequence (324 amino acids)

>Ac3H11_3452 Ribose-phosphate pyrophosphokinase (EC 2.7.6.1) (Acidovorax sp. GW101-3H11)
MQANHPDFMVFTGNANPGMAAEIAQHLGTTLGAADVGRFSDGEVTVEIKQNVRARDVFVV
QSTCAPTNENLMELLIMVDALKRASAERISAVIPYFGYARQDRRPRSTRVPITAKVVANM
LQAVGVARVLTMDLHADQIQGFFDIPVDNIYASPVLLGDLRQKNYEDLIVVSPDVGGVVR
ARALAKQLGCDLAIIDKRRPKANVSEVMHVIGEIEGRNCVIMDDMIDTAGTLVKAAEVLK
ERGAKSVYAYCTHPIFSGPAIERIAKGSALDEVVVTNTIPLSDNAKGCTKIRQLSVAPLI
AETIQRIAKGESVMSLFSDQDNLF