Protein Info for Ac3H11_2576 in Acidovorax sp. GW101-3H11

Annotation: 5-Enolpyruvylshikimate-3-phosphate synthase (EC 2.5.1.19) / Cytidylate kinase (EC 2.7.4.25)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00275: EPSP_synthase
  • amino acids 15 to 440 (426 residues), 400.3 bits, E=1.4e-123
• TIGR01356: 3-phosphoshikimate 1-carboxyvinyltransferase
  • amino acids 17 to 443 (427 residues), 439.5 bits, E=1.2e-135
• TIGR00017: cytidylate kinase
  • amino acids 452 to 662 (211 residues), 227.2 bits, E=1.8e-71
• PF13189: Cytidylate_kin2
  • amino acids 453 to 628 (176 residues), 29.7 bits, E=1.1e-10
• PF02224: Cytidylate_kin
  • amino acids 454 to 663 (210 residues), 234.8 bits, E=1.4e-73

Best Hits

KEGG orthology group: K00800, 3-phosphoshikimate 1-carboxyvinyltransferase [EC: 2.5.1.19] (inferred from 82% identity to aav:Aave_3284)

Predicted SEED Role

"5-Enolpyruvylshikimate-3-phosphate synthase (EC 2.5.1.19) / Cytidylate kinase (EC 2.7.4.25)" in subsystem Chorismate Synthesis or Common Pathway For Synthesis of Aromatic Compounds (DAHP synthase to chorismate) (EC 2.5.1.19, EC 2.7.4.25)

MetaCyc Pathways

• superpathway of aromatic amino acid biosynthesis (18/18 steps found)
• superpathway of L-tryptophan biosynthesis (13/13 steps found)
• superpathway of L-phenylalanine biosynthesis (10/10 steps found)
• superpathway of L-tyrosine biosynthesis (10/10 steps found)
• chorismate biosynthesis I (7/7 steps found)
• superpathway of chorismate metabolism (44/59 steps found)
• chorismate biosynthesis from 3-dehydroquinate (5/5 steps found)
• pyrimidine deoxyribonucleotide phosphorylation (4/4 steps found)
• CMP phosphorylation (2/2 steps found)
• chorismate biosynthesis II (archaea) (8/12 steps found)
• superpathway of pyrimidine ribonucleosides salvage (6/10 steps found)
• superpathway of pyrimidine deoxyribonucleoside salvage (5/9 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of phenylpropanoids
• Biosynthesis of plant hormones
• Phenylalanine, tyrosine and tryptophan biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.5.1.19 or 2.7.4.25

Sequence Analysis Tools

See A0A162DL09 at UniProt or InterPro

Protein Sequence (676 amino acids)

>Ac3H11_2576 5-Enolpyruvylshikimate-3-phosphate synthase (EC 2.5.1.19) / Cytidylate kinase (EC 2.7.4.25) (Acidovorax sp. GW101-3H11)
MYSTVFLDLPPLQAAAGEVHLPGSKSISNRVLLLAALSNGTTTVHDLLASDDTRVMLDAL
RQIGCTVDEAGSTVRITGLGGRLPQSPAKLFLGNAGTAMRPLTAALALLGGEFELSGVPR
MHERPIGDLIDALRQLGCQIDYLGNEGYPPLKIAHGQGVPSLALAEPIRVRGDVSSQFLT
ALLMALPLAAGTQAIVIEVVGELISKPYIAITLQLLARFGIVVGHQNWQRFTIPAGSRYQ
SPGSIHVEADASSASYFIALGAIATGGEAQKSIKIQGVGLDSIQGDIRFVEAARAMGAVV
TGGPNWLQIERGAWPLKAIELDCNHIPDAAMTLAVMALYAEGTTTLTNIASWRVKETDRI
AAMATELRKLGATVEEGADYIRVTPPTQAADWKAASIHTYDDHRVAMCFSLAAFNPARLP
VRIEDPKCVAKTFPDYFEALFSVAQVETAHIPVICIDGPTASGKGTVAAAVAQRLGYRFL
DSGAMYRITALAALRAGLAIDADHEARIATMAQTLPVRFEGGKVWLGSDDVTDAIRTEEA
GMNASRVSALPAVRTALVDLQHSFQRLPGLVADGRDMGTVIFPEAPLKVYLTASAACRAE
RRYKQLISKGFSASIEDLRADLEARDARDSSRSVAPLKPAQDALVLDNSTLTIDEAVEQV
LAWWQERQPFAGSAQG