Protein Info for Ac3H11_2535 in Acidovorax sp. GW101-3H11

Annotation: Peptide methionine sulfoxide reductase MsrB (EC 1.8.4.12)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00357: methionine-R-sulfoxide reductase
  • amino acids 7 to 132 (126 residues), 169.1 bits, E=2.5e-54
• PF01641: SelR
  • amino acids 22 to 133 (112 residues), 169.3 bits, E=1.6e-54

Best Hits

Swiss-Prot: 83% identical to MSRB_VARPS: Peptide methionine sulfoxide reductase MsrB (msrB) from Variovorax paradoxus (strain S110)

KEGG orthology group: K07305, peptide-methionine (R)-S-oxide reductase [EC: 1.8.4.12] (inferred from 91% identity to aav:Aave_2948)

MetaCyc: 55% identical to methionine sulfoxide reductase B (Escherichia coli K-12 substr. MG1655)
L-methionine (R)-S-oxide reductase. [EC: 1.8.4.14]; Peptide-methionine (R)-S-oxide reductase. [EC: 1.8.4.14, 1.8.4.12]

Predicted SEED Role

"Peptide methionine sulfoxide reductase MsrB (EC 1.8.4.12)" (EC 1.8.4.12)

KEGG Metabolic Maps

• Methionine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.8.4.12 or 1.8.4.14

Sequence Analysis Tools

See A0A165KW08 at UniProt or InterPro

Protein Sequence (137 amino acids)

>Ac3H11_2535 Peptide methionine sulfoxide reductase MsrB (EC 1.8.4.12) (Acidovorax sp. GW101-3H11)
MTHPIQKTDAEWQAVLREKGAEPVAFQVTRHAATERPFTGKYETHWADGSYHCICCDAKL
FDSDTKFDAGCGWPSFSQAIPGAITEIVDRSHGMVRTETVCAQCGAHLGHVFEDGPAPTG
LRYCMNSASLDFESDKG