Protein Info for Ac3H11_2466 in Acidovorax sp. GW101-3H11
Annotation: Dihydrolipoamide succinyltransferase component (E2) of 2-oxoglutarate dehydrogenase complex (EC 2.3.1.61)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 78% identical to ODO2_CUPNH: Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex (sucB) from Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337)
KEGG orthology group: K00658, 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) [EC: 2.3.1.61] (inferred from 91% identity to del:DelCs14_3327)Predicted SEED Role
"Dihydrolipoamide succinyltransferase component (E2) of 2-oxoglutarate dehydrogenase complex (EC 2.3.1.61)" in subsystem TCA Cycle (EC 2.3.1.61)
MetaCyc Pathways
- 2-oxoglutarate decarboxylation to succinyl-CoA (3/3 steps found)
KEGG Metabolic Maps
- Biosynthesis of alkaloids derived from histidine and purine
- Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
- Biosynthesis of alkaloids derived from shikimate pathway
- Biosynthesis of alkaloids derived from terpenoid and polyketide
- Biosynthesis of phenylpropanoids
- Biosynthesis of plant hormones
- Biosynthesis of terpenoids and steroids
- Citrate cycle (TCA cycle)
- Lysine degradation
Isozymes
No predicted isozymesUse Curated BLAST to search for 2.3.1.61
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A165KUU0 at UniProt or InterPro
Protein Sequence (422 amino acids)
>Ac3H11_2466 Dihydrolipoamide succinyltransferase component (E2) of 2-oxoglutarate dehydrogenase complex (EC 2.3.1.61) (Acidovorax sp. GW101-3H11) MAIVEVKVPQLSESVAEATMLTWKKKAGEAVTVDEILIEIETDKVVLEVPAPSAGVLSEI IQGDGATVVAEQLIAKIDTEGKAGAAAAAPAAAAPAPAAAAPAAAPAAAGGSKGDVAMPA AAKLLADNNLSVSAVAGSGKDGRVTKGDVLAAVAGGAKAAVAAPSVIPTGVPSKALPQVA APAGKEDLSGRPEQRVPMSRLRARVAERLLQSQSTNAILTTFNEVNMAPVMDLRKKFQDS FTKEHGAKLGFMSFFVKAAVHALKKYPVLNASVDGNDIVYHGYFDIGIAVGSPRGLVVPI LRNADQMSFADIEKKIAEFGKKAAEGKLGIEEMTGGTFSISNGGTFGSMMSTPIINPPQS AILGVHATKDRAMVENGQVVVRPMNYLAMSYDHRIIDGREAVLGLVAMKDALEDPSRLLF DI