Protein Info for Ac3H11_2372 in Acidovorax sp. GW101-3H11

Annotation: Phytochrome, two-component sensor histidine kinase (EC 2.7.3.-)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 626 TIGR00229: PAS domain S-box protein" amino acids 17 to 132 (116 residues), 77.4 bits, see alignment E=5.2e-26 amino acids 137 to 260 (124 residues), 83.1 bits, see alignment E=9e-28 amino acids 259 to 382 (124 residues), 79.8 bits, see alignment E=9.3e-27 PF08448: PAS_4" amino acids 19 to 127 (109 residues), 39.5 bits, see alignment E=2.3e-13 amino acids 144 to 256 (113 residues), 36.8 bits, see alignment E=1.6e-12 amino acids 265 to 377 (113 residues), 44.5 bits, see alignment E=6.6e-15 PF00989: PAS" amino acids 20 to 118 (99 residues), 69.9 bits, see alignment E=7.5e-23 amino acids 139 to 251 (113 residues), 51.5 bits, see alignment E=4e-17 amino acids 261 to 371 (111 residues), 54.1 bits, see alignment E=6.2e-18 PF13426: PAS_9" amino acids 23 to 126 (104 residues), 45.6 bits, see alignment E=3e-15 amino acids 148 to 253 (106 residues), 57.6 bits, see alignment E=5.3e-19 amino acids 269 to 374 (106 residues), 60.9 bits, see alignment E=5.1e-20 PF08447: PAS_3" amino acids 36 to 118 (83 residues), 36.3 bits, see alignment E=2.3e-12 PF13188: PAS_8" amino acids 138 to 191 (54 residues), 37.9 bits, see alignment 4.6e-13 amino acids 259 to 311 (53 residues), 38.5 bits, see alignment 3e-13 PF00512: HisKA" amino acids 396 to 462 (67 residues), 68.5 bits, see alignment E=1.7e-22 PF02518: HATPase_c" amino acids 510 to 623 (114 residues), 97.1 bits, see alignment E=3.5e-31

Best Hits

KEGG orthology group: K05962, protein-histidine pros-kinase [EC: 2.7.13.1] (inferred from 59% identity to azo:azo1492)

Predicted SEED Role

"Phytochrome, two-component sensor histidine kinase (EC 2.7.3.-)" in subsystem Oxidative stress or Oxygen and light sensor PpaA-PpsR (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.3.-

Use Curated BLAST to search for 2.7.13.1 or 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A162F7H4 at UniProt or InterPro

Protein Sequence (626 amino acids)

>Ac3H11_2372 Phytochrome, two-component sensor histidine kinase (EC 2.7.3.-) (Acidovorax sp. GW101-3H11)
LEQEAQEGCMGSKLSVAYWEQNPDALLVLSPEGLVLEWNPAAELIFGYKQADVQGRSLLD
LIVPPDRAHEEDIMRAEAVNMGSSVRETVRRRKDGTLVHINVSTKAVLDGSGQLLYFLSS
KKDVTQLKVEREAKLLEARFRDLLESTPDAIVMVNVTGRIVLVNSQAERVFGYPRAELLG
QAIEMLLPHRYRGAHLGHRSGFFGQPRTRTMGAGLELHGLHKDRGEFPVEISLSPIDTEE
GTMVMSAIRDITDRKRADQKFKDLLEAAPDAMVIVNREGRIVLVNSQAVKLFGWSRDELL
GQPIELLVPERFGARHPEHRHRFFAEPRSRSMGAGLDLYGLRKDKSEFPVEISLSPLETE
EGLFVSSAIRDVTERKRIEQVLRDKNLELENAALVKDRFLASMSHELRTPLNAIIGFTGT
LLMKLPGPLNAEQEKQLRIVQTGAKHLLSLINDLLDVAKLSANKVTLNLEAVDCKALIEE
VSATLELEARRKGLAFAVHVPTQAVALQTDRRALSQILINLVGNAIKFTEQGRVDVVLHE
LPMPDGGRSVQLRVQDTGPGIALQEQPRLFEAFSRVESADRRHHEGTGLGLHLSRKLAEA
LGGTLGFDSEEGRGSTFVLEIQERSA