Protein Info for Ac3H11_2370 in Acidovorax sp. GW101-3H11

Annotation: diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1222 transmembrane" amino acids 609 to 622 (14 residues), see Phobius details amino acids 723 to 746 (24 residues), see Phobius details PF00072: Response_reg" amino acids 4 to 117 (114 residues), 86.9 bits, see alignment E=4.8e-28 PF13185: GAF_2" amino acids 174 to 315 (142 residues), 42.3 bits, see alignment E=4.1e-14 amino acids 627 to 772 (146 residues), 75.9 bits, see alignment E=1.7e-24 PF08447: PAS_3" amino acids 376 to 454 (79 residues), 35.5 bits, see alignment 4.4e-12 amino acids 505 to 587 (83 residues), 32.5 bits, see alignment 3.8e-11 TIGR00229: PAS domain S-box protein" amino acids 479 to 603 (125 residues), 73.7 bits, see alignment E=1.5e-24 PF00989: PAS" amino acids 484 to 594 (111 residues), 46.3 bits, see alignment E=1.8e-15 PF08448: PAS_4" amino acids 491 to 599 (109 residues), 32.7 bits, see alignment E=3.5e-11 PF13426: PAS_9" amino acids 501 to 596 (96 residues), 41.2 bits, see alignment 8.1e-14 PF01590: GAF" amino acids 681 to 770 (90 residues), 35.5 bits, see alignment 6.4e-12 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 782 to 944 (163 residues), 75.1 bits, see alignment E=5.3e-25 PF00990: GGDEF" amino acids 784 to 938 (155 residues), 98.2 bits, see alignment E=2.1e-31 PF00563: EAL" amino acids 962 to 1196 (235 residues), 250.6 bits, see alignment E=6.1e-78

Best Hits

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A165KT14 at UniProt or InterPro

Protein Sequence (1222 amino acids)

>Ac3H11_2370 diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s) (Acidovorax sp. GW101-3H11)
MAKILVVDDLPANRALVVTLIGHSGHQALEAADGAEALALVRAERPDLVISDILMPTMDG
YEFVRQLRADHHLAATQVIFYSAHYREQEARNLALACGVTQVLVKPCEPQDILAAIEQAL
TQIAPRPSVALEHGFQTRHLQLVTDKLTGNVAELEAMNRRLAALTDLNLQLASERDPQVL
LANVCRGARELVGAQYAVLCVVRKHSGSAITCTSGIDPARTGPQDRPLDLPVVSHGLLGQ
LRADRRSERVTNPGGNPSVIGLPAGYPPLHTGLIAPVTSLSFSYGWICLANKEGAEEFSA
DDEKVLAILGAQVGRIYENGSLYMEVQKHAEQLQVEVFERQRAMDELRASKVSLRRAQAL
AKITHVISGHDGAFESWQDTLPDILGLPADAVPRSAREWLELVHPHDRGTFRHHALQAAR
QRIRVDFTYRVLNPSGELQYLRQVMEPLEDETGRGTVGRWFNTIQDVTKEKRAEEELHES
DRRFNTMLDKVEMISLMLDCTGLITYCNDYLLRLTGWQREEVFGRNWFELFVPPETAHVR
DVFADLLADRPSAWHYDNEILTRSGERRLVHWNNTVLRSVGGQVTGVASLGEDITERREA
ERKIKRLNRVYAMLSGINTLIVRVRQRDELFREACRIAVDHGHFRIAWIGRVDRAARRVV
PVGVSGAEADFIHNIHDRLGLFDVPTPEESLAAAVVRSGRPVLCDDITGDPRVMLREQLQ
ARGVASIAVLPIVVAGDVVAVVALLADEVGFFDAAEMKLLTELAGDIGFAMDHLDKEDRL
SYLAYYDEITGLPNRTLFLERTGQHLRARDGAKALHGVALMDVSRFRIVNDTLGRQAGDE
LLKQVALRLQHAASNLHDVARIGINSFGIAVTEARDAGAVAVAVDLLMRACFDTPFVVGG
TELRMAAKAGVALYPMDGADAETLLRNAEAAVNKAKASADSLLFYTSEMNTRVAEALSLE
GRLRAALEQGQFVLHYQPKQHLASGAITGVEALIRWNDPRRGLVPPGQFIPILEETGLIY
DVGRWALRQALADNLRWRQAGLAPLRVAVNVSILQLRHQGFIAEVRDAVAHDAAAASGLE
LEITESMVMDDVERSTQSLHALREMGITIAIDDFGTGFSSLSYLARLPVDTLKIDRSFTM
NMASGPQGLSLVSTIVNLGHSLRLKVVAEGVETEDQRARLAQLGCDEMQGYLLSQPLPAS
AFEQRFLRAAAPSGAAVSVPVP