Protein Info for Ac3H11_2341 in Acidovorax sp. GW101-3H11

Annotation: D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00389: 2-Hacid_dh
  • amino acids 43 to 314 (272 residues), 73.5 bits, E=2.1e-24
• PF02826: 2-Hacid_dh_C
  • amino acids 113 to 285 (173 residues), 188.3 bits, E=1.2e-59
• PF03446: NAD_binding_2
  • amino acids 151 to 255 (105 residues), 21.7 bits, E=2.6e-08

Best Hits

Swiss-Prot: 46% identical to HPPR_PLESU: Hydroxyphenylpyruvate reductase (HPPR) from Plectranthus scutellarioides

KEGG orthology group: None (inferred from 65% identity to ajs:Ajs_1991)

MetaCyc: 46% identical to hydroxyphenylpyruvate reductase (Coleus scutellarioides)
Hydroxyphenylpyruvate reductase. [EC: 1.1.1.237]; 1.1.1.237 [EC: 1.1.1.237]

Predicted SEED Role

"D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95)" in subsystem Glycine and Serine Utilization or Pyridoxin (Vitamin B6) Biosynthesis or Serine Biosynthesis (EC 1.1.1.95)

MetaCyc Pathways

• superpathway of sulfate assimilation and cysteine biosynthesis (9/9 steps found)
• superpathway of L-serine and glycine biosynthesis I (4/4 steps found)
• L-serine biosynthesis I (3/3 steps found)
• L-cysteine biosynthesis IX (Trichomonas vaginalis) (2/3 steps found)
• rosmarinic acid biosynthesis II (1/4 steps found)
• rosmarinic acid biosynthesis I (3/10 steps found)
• superpathway of rosmarinic acid biosynthesis (4/14 steps found)

KEGG Metabolic Maps

• Alkaloid biosynthesis II
• Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
• Glycine, serine and threonine metabolism
• Phenylalanine metabolism
• Tyrosine metabolism
• Ubiquinone and menaquinone biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.95

Use Curated BLAST to search for 1.1.1.237 or 1.1.1.95

Sequence Analysis Tools

See A0A165KSN1 at UniProt or InterPro

Protein Sequence (322 amino acids)

>Ac3H11_2341 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) (Acidovorax sp. GW101-3H11)
MTTNAQPRILQIGRLPLPALETELAARYSVACLADQADPQGFLAAQGAEFSGVVTTASIG
LQGEVIAALPHLQVISSFGVGFDALDIGTATARGVQVGYTPGVLNDCVADMAFALMLDVS
RGIAASDRFVRQGQWPKARFALGTRVSGKRLGIVGMGRIGQAVAERAAGFRMEVSYHNRR
PAEGCALSYFESLTALAQWADYLVLTVAGGAGTRHLVNRDVLDALGPQGYLINVARGSVV
DEAALIDALAERRIAGAGLDVFDNEPQVPAALMALDNVVLTPHTASATHETRRAMADLVL
ENLHAFYTSGAVRVPVPGTVAG