Protein Info for Ac3H11_2218 in Acidovorax sp. GW101-3H11

Annotation: diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 766 transmembrane" amino acids 6 to 25 (20 residues), see Phobius details amino acids 33 to 52 (20 residues), see Phobius details amino acids 58 to 77 (20 residues), see Phobius details amino acids 88 to 109 (22 residues), see Phobius details amino acids 115 to 135 (21 residues), see Phobius details amino acids 142 to 159 (18 residues), see Phobius details amino acids 173 to 194 (22 residues), see Phobius details TIGR00229: PAS domain S-box protein" amino acids 195 to 321 (127 residues), 41.1 bits, see alignment E=1.8e-14 PF00989: PAS" amino acids 199 to 311 (113 residues), 25.7 bits, see alignment E=2.4e-09 PF13426: PAS_9" amino acids 210 to 314 (105 residues), 34.3 bits, see alignment E=5.8e-12 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 324 to 486 (163 residues), 135.8 bits, see alignment E=1.2e-43 PF00990: GGDEF" amino acids 326 to 484 (159 residues), 156.5 bits, see alignment E=1.3e-49 PF00563: EAL" amino acids 506 to 741 (236 residues), 259.1 bits, see alignment E=9.1e-81

Best Hits

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A168F710 at UniProt or InterPro

Protein Sequence (766 amino acids)

>Ac3H11_2218 diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s) (Acidovorax sp. GW101-3H11)
VVPVHDLGVAALAILGVAFLIGWSSARLNQATLLWGIAHLSLAGATFTGYRYHLQPESLW
LGVMATLLTGFFLASLHGGTNFLRGRIIGPGTLIGRSLGVAFLIAVVGIGGDKRAASILV
LGLMMLVYGVSAYLCLRMHYRLLAAAFSLKTAAFLLYFLEPSTIGTPFQNPDILSVGWVS
SVLLGLVLVDAAIAQTRQRLSNVIKHLPDALVARRLDGKILFCNDRFAQLAGSASPAELE
GQQVPLLTREQEEAEAMFRKVNAMVQSGPMDAPMRLERAVTPARGEPFPAEIIFSSYMDL
GYPVILGLIRDLSERKRGEEERLHQANTDQLTGLPNRRFLEQQLDAVLWIAHRQHTQCAV
LLIDLDHFKKVNDTLGHAFGDELLREIAQALQDQLRPGDLLARLSGDEFALVMAGLPSLM
SILEVEARALALLQLIRRQFKSDGMDYQIEASIGVAFSTREGLSAPVLLQRAEVAMYESK
ARGRGGWCFFESDMDERLAESLRLESALRQAVPRGELRLHYQPIYSCSTGRMTKAEALVR
WENPQLGWVPPGRFIPAAEESSLILEVGQWILEEAIRQAAQWRAQSGLAPVISINVSVRQ
FAQPGFESQVFALLERYGVPPAGIELELTETLLASDQEDLPALLHRLHDAGVGLSLDDFG
TGYSSLSYLSRFSLNTVKIDRSFVMGLQESSRNHSLVRAIISMAHSLHLNVVAEGVETWR
QYEILKAEGCDYLQGYLLGRPMAADQLRAHPQVLAGEESNIPDAVI