Protein Info for Ac3H11_212 in Acidovorax sp. GW101-3H11
Annotation: Gentisate 1,2-dioxygenase (EC 1.13.11.4)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 59% identical to SDGD_STRSQ: Gentisate 1,2-dioxygenase (sdgD) from Streptomyces sp.
KEGG orthology group: K00450, gentisate 1,2-dioxygenase [EC: 1.13.11.4] (inferred from 78% identity to ctt:CtCNB1_2778)MetaCyc: 60% identical to salicylate 1,2-dioxygenase subunit (Pseudaminobacter salicylatoxidans BN12)
1.13.11.-
Predicted SEED Role
"Gentisate 1,2-dioxygenase (EC 1.13.11.4)" in subsystem Gentisare degradation or Salicylate and gentisate catabolism (EC 1.13.11.4)
MetaCyc Pathways
- gentisate degradation I (3/3 steps found)
- gentisate degradation II (2/4 steps found)
- 3-phenylpropanoate degradation (6/10 steps found)
- salicylate degradation IV (2/5 steps found)
- 2,5-xylenol and 3,5-xylenol degradation (3/13 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 1.13.11.4
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A165JKY9 at UniProt or InterPro
Protein Sequence (374 amino acids)
>Ac3H11_212 Gentisate 1,2-dioxygenase (EC 1.13.11.4) (Acidovorax sp. GW101-3H11) MTTDLTPSPVRLHAVAGKGQPEPTPELEQLYRGFEQELLVPLWTQIGDLMPRQPQSKAVP HLWRWDRLKALAAQAGAIVPVGRGGERRAIALANPALGGRPFATPTLWAAIQYLMPGEDA PEHRHTQHAFRFVVEGEGVWTVVNGDAVRMSRGDFLPQAGWNWHAHHNAATEPMAWIDGL DIPFSYYTESQFFEVGREKLPPAERTTAERSYSERLWGHPGLRPVSMVQAQPATPLLAYR WVDTDRALADQLALEDEGQAGTLSPGHAAVRFTNPTTGADVLPTMRTEMHRVRAGGATRV QREVGSSVFQVFDGSGTVTVGERTWQVARGDLFVVPSWQPFSAQASAAGALDLFRFSDAP IFEVLHSHRVQVTV