Protein Info for Ac3H11_2009 in Acidovorax sp. GW101-3H11

Annotation: Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 581 signal peptide" amino acids 1 to 41 (41 residues), see Phobius details PF03717: PBP_dimer" amino acids 65 to 215 (151 residues), 80.6 bits, see alignment E=2.1e-26 PF00905: Transpeptidase" amino acids 257 to 553 (297 residues), 252.5 bits, see alignment E=5.3e-79

Best Hits

Swiss-Prot: 43% identical to PBP2_NEIMA: Probable peptidoglycan D,D-transpeptidase PenA (penA) from Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)

KEGG orthology group: K03587, cell division protein FtsI (penicillin-binding protein 3) [EC: 2.4.1.129] (inferred from 89% identity to aaa:Acav_0746)

Predicted SEED Role

"Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129)" in subsystem Bacterial Cell Division or Bacterial Cytoskeleton or Flagellum in Campylobacter or Peptidoglycan Biosynthesis (EC 2.4.1.129)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.4.1.129

Use Curated BLAST to search for 2.4.1.129

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A165KNR4 at UniProt or InterPro

Protein Sequence (581 amino acids)

>Ac3H11_2009 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) (Acidovorax sp. GW101-3H11)
MSRSVVYTASPLLASKTPVWRSKFIVAMIALGFVGLGARAAYVQVFGNDFFQRQGEVRFA
RTLELPANRGKILDRNGLILASSVPAASIWAIPEDVDQDKPEVRAKLKQLAKLLDMPQAE
LMKKLADEDKTFVWVKRQLDWDVGQQIAKLDIKGIYQRKEYKRQYPEGEAAAHVVGFTNV
EDHGQEGMELAFNKDLAGKPGSRRVIKDRLGRVVEGVGETVPPVDGKDMQLSIDSKVQFF
AYQKLRDQVTAHKAKAGSVVVLDAHTGEVLALANYPSYVPDKRQNLTGEQLRNRALTDTF
EPGSTMKPITIGLALESGRVRPETVVDTTPGRINITGSTISDTHNYGVLTVEGVIQKSSN
VGTTKLAMQMPAREMWETFSAAGFGQKPQIDFPGAVSGRLRPYKSWRPVEQATMSYGYGL
SASLFQMARSYTVFANSGRVIPATMLKSEQPAVGVPVFSERTADQVRKMLQMAAGPGGTG
QKAQTVGYSVGGKSGTARKQVGKNYAVGKYRAWFTGMAPIDKPRIVVAVMIDEPSNGVYY
GGAVAAPVFSEVVQQTLRMMGVQPDMAVKPQIVANAVEESL