Protein Info for Ac3H11_1965 in Acidovorax sp. GW101-3H11

Annotation: Heat shock protease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 292 transmembrane" amino acids 7 to 26 (20 residues), see Phobius details amino acids 38 to 59 (22 residues), see Phobius details amino acids 158 to 177 (20 residues), see Phobius details amino acids 195 to 219 (25 residues), see Phobius details PF01435: Peptidase_M48" amino acids 81 to 288 (208 residues), 144.4 bits, see alignment E=1.9e-46

Best Hits

Swiss-Prot: 91% identical to HTPX_ACIAC: Protease HtpX homolog (htpX) from Acidovorax citrulli (strain AAC00-1)

KEGG orthology group: K03799, heat shock protein HtpX [EC: 3.4.24.-] (inferred from 91% identity to aaa:Acav_4219)

Predicted SEED Role

"Heat shock protease"

Isozymes

Compare fitness of predicted isozymes for: 3.4.24.-

Use Curated BLAST to search for 3.4.24.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A165KMQ4 at UniProt or InterPro

Protein Sequence (292 amino acids)

>Ac3H11_1965 Heat shock protease (Acidovorax sp. GW101-3H11)
MKRILLFVMTNLAVVVVLGVVASLLGVNRYLTANGLNLGALLGFALIMGFGGAIISLLIS
KPMAKWTSGVRVIDGSGSPDERWIVETVRKFADKAGIGMPEVGIFEGDPNAFATGAFKNS
ALVAVSTGLLQGMTRDEVEAVIGHEVAHIANGDMVTMTLIQGVMNTFVVFLSRLIGYAVD
SFLRKNDENSSGPGIGYYVTTIVLDIVLGFAAAIIVAWFSRQREFRADAGAAQLMGRRQP
MINALARLGGMHPGELPKSVAAMGIAGGIGKLFSTHPPIEERIAALQNAQQQ