Protein Info for Ac3H11_1927 in Acidovorax sp. GW101-3H11

Annotation: Methylcrotonyl-CoA carboxylase biotin-containing subunit (EC 6.4.1.4)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 670 PF00289: Biotin_carb_N" amino acids 1 to 109 (109 residues), 144.6 bits, see alignment E=4.6e-46 PF02786: CPSase_L_D2" amino acids 119 to 320 (202 residues), 223.2 bits, see alignment E=8.1e-70 PF02785: Biotin_carb_C" amino acids 334 to 446 (113 residues), 91.1 bits, see alignment E=1.4e-29 PF00364: Biotin_lipoyl" amino acids 595 to 660 (66 residues), 43 bits, see alignment E=9.6e-15 PF13533: Biotin_lipoyl_2" amino acids 633 to 661 (29 residues), 25.1 bits, see alignment (E = 3.6e-09)

Best Hits

Predicted SEED Role

"Methylcrotonyl-CoA carboxylase biotin-containing subunit (EC 6.4.1.4)" in subsystem HMG CoA Synthesis or Leucine Degradation and HMG-CoA Metabolism or Serine-glyoxylate cycle (EC 6.4.1.4)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 6.4.1.4

Use Curated BLAST to search for 6.4.1.4

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A165KLF9 at UniProt or InterPro

Protein Sequence (670 amino acids)

>Ac3H11_1927 Methylcrotonyl-CoA carboxylase biotin-containing subunit (EC 6.4.1.4) (Acidovorax sp. GW101-3H11)
MKKILIANRSEIARRIIHTAHRMGIETVAVYSDPDASALHVREATQAVALGGAASADTYL
RTDKLLAAARATGADAVHPGYGFLSENADFAQAVVDAGLTWIGPPPAAIRALGSKAGAKA
LAVAHCVPCLPGYAGDDQSDERFAAEAARIGTPLMVKAVAGGGGRGMRLVTDLAQLPAAL
ASARSEALAGFGCGDLLIERALLQPRHVEVQIFADAHGACIHLGERDCSVQRRHQKIIEE
APSPAVDAALRERMGACAVALAQAAGYVGAGTVEFLLDGPDFYLMEMNTRLQVEHPVTEA
LTGLDLVEWQIRVARGEPLPLTQDQVHLQGHAIEVRLCAEDAHFRPHTGRVLQFSAPPAT
AFERAAPGALRFDHALEEGAEVTPHYDAMLGKLIVHAPTRAEAIAALVRALHSTRVLGLP
TNRAFLAACLQHPVFGAGHALVPFLAEHAAQLQGLLSNIELKVLVQSAVAVIFSSNSSGA
ASAQLPCALARPLRLRHQGQVVPLAVRELGAGRLWVEHAGGTTHLQLAPQAAGMVRITTM
QTGAVGEVHHADHTVRAVPVGPRRWHWQTGGVDGWVEDASWEPAARAGAAGGATELRAPF
NGKVVALPVAAGQALSAGDTVVVIESMKLEHSLASPVAATVAELLVAPGQQVSPGQVLAR
FAPATQGAPA