Protein Info for Ac3H11_1805 in Acidovorax sp. GW101-3H11

Annotation: Adenylosuccinate synthetase (EC 6.3.4.4)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00709: Adenylsucc_synt
  • amino acids 10 to 449 (440 residues), 569.8 bits, E=1.6e-175
• TIGR00184: adenylosuccinate synthase
  • amino acids 10 to 455 (446 residues), 533.4 bits, E=1.9e-164

Best Hits

Swiss-Prot: 93% identical to PURA_VEREI: Adenylosuccinate synthetase (purA) from Verminephrobacter eiseniae (strain EF01-2)

KEGG orthology group: K01939, adenylosuccinate synthase [EC: 6.3.4.4] (inferred from 93% identity to vei:Veis_3162)

Predicted SEED Role

"Adenylosuccinate synthetase (EC 6.3.4.4)" in subsystem CBSS-262719.3.peg.410 or Purine conversions (EC 6.3.4.4)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (42/46 steps found)
• superpathway of purine nucleotides de novo biosynthesis I (21/21 steps found)
• superpathway of purine nucleotides de novo biosynthesis II (23/26 steps found)
• superpathway of purine nucleotide salvage (12/14 steps found)
• superpathway of adenosine nucleotides de novo biosynthesis I (5/5 steps found)
• superpathway of adenosine nucleotides de novo biosynthesis II (6/7 steps found)
• adenosine ribonucleotides de novo biosynthesis (3/3 steps found)

KEGG Metabolic Maps

• Alanine and aspartate metabolism
• Biosynthesis of alkaloids derived from histidine and purine
• Purine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.4.4

Sequence Analysis Tools

See A0A165HXW6 at UniProt or InterPro

Protein Sequence (458 amino acids)

>Ac3H11_1805 Adenylosuccinate synthetase (EC 6.3.4.4) (Acidovorax sp. GW101-3H11)
MKATKGRNVVVVGTQWGDEGKGKLVDWLTESAQGVVRFQGGHNAGHTLVINGVKTALHLI
PSGIMRPGVKCYIGNGVVLSAAKLFEEIEGLEKAGVEVRSRLRISEACPLILPFHAAIDV
AREAAREQGGTEKIGTTGRGIGPAYEDKIARRALRVQDLKFPERFASKLRELLDLHNHVL
TTYLGSAKFVFGDALKPYLQDGKVQFDVVYAEAMRHAELLRPMMADVSRELNEANQAGAN
LLFEGAQGTLLDVDHGTYPYVTSSNCVAGNAAAGSGVGPGMLHYILGITKAYCTRVGGGP
FPTELDWEVPGTPGYHMSTVGAEKGVTTGRSRRCGWFDAALLKRSAQVNGLSGLCITKLD
VLDGLTELLLCTGYELDGERIDLLPMGADDIARCTPIYEALPGWSESTVGVTDYAKLPES
ARRYLERIEQVTGVPIAMISTSPDRDHTIMMRHPYVAG