Protein Info for Ac3H11_1800 in Acidovorax sp. GW101-3H11

Annotation: GTP-binding protein HflX

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 373 TIGR03156: GTP-binding protein HflX" amino acids 10 to 352 (343 residues), 461.9 bits, see alignment E=6e-143 PF13167: GTP-bdg_N" amino acids 11 to 97 (87 residues), 99.3 bits, see alignment E=5.4e-32 PF16360: GTP-bdg_M" amino acids 99 to 178 (80 residues), 95.7 bits, see alignment E=6.9e-31 PF00009: GTP_EFTU" amino acids 183 to 351 (169 residues), 30.8 bits, see alignment E=7.4e-11 PF02421: FeoB_N" amino acids 185 to 347 (163 residues), 29.9 bits, see alignment E=1.3e-10 PF01926: MMR_HSR1" amino acids 186 to 305 (120 residues), 82.6 bits, see alignment E=8.3e-27

Best Hits

Swiss-Prot: 40% identical to HFLX_TREDE: GTPase HflX (hflX) from Treponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222)

KEGG orthology group: K03665, GTP-binding protein HflX (inferred from 88% identity to vei:Veis_0074)

Predicted SEED Role

"GTP-binding protein HflX" in subsystem Hfl operon or Universal GTPases

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A165HXZ9 at UniProt or InterPro

Protein Sequence (373 amino acids)

>Ac3H11_1800 GTP-binding protein HflX (Acidovorax sp. GW101-3H11)
VDFGLPHFDGELEELGLLAQTAGMQPVARITCKRKAPDAALFVGSGKADEIRTLAQMHGA
VEVLFDQSLSPAQQRNLERHIELPVNDRTLLILEIFAQRARSHEGKLQVELAKLQYVSTR
LVRRWSHLERQTGGIGARGGPGEKQIELDRRMIGDAIKRTRERLVKVKRQRSTQRRQRER
RDTFNISLVGYTNAGKSTLFNALVKARAYAADQLFATLDTTTRQLYLADAGRSVSLSDTV
GFIRDLPHGLVDAFQATLQEAIDADLLLHVVDASNADFPEQMAQVERVLQEIGAADIPQI
LVFNKLDALADERRPPELQDQYEVAGHLLPRLFVSARSGEGLDHLRHALATRVLATQLDM
TPGDAVELPDAMP