Protein Info for Ac3H11_1767 in Acidovorax sp. GW101-3H11

Annotation: L-lactate dehydrogenase (EC 1.1.2.3)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01070: FMN_dh
  • amino acids 50 to 415 (366 residues), 416.8 bits, E=3.4e-129

Best Hits

KEGG orthology group: K00101, L-lactate dehydrogenase (cytochrome) [EC: 1.1.2.3] (inferred from 86% identity to dac:Daci_0789)

Predicted SEED Role

"L-lactate dehydrogenase (EC 1.1.2.3)" in subsystem L-rhamnose utilization or Lactate utilization or Respiratory dehydrogenases 1 (EC 1.1.2.3)

MetaCyc Pathways

• methylglyoxal degradation V (2/3 steps found)
• lactate fermentation to acetate, CO₂ and hydrogen (Desulfovibrionales) (2/8 steps found)

KEGG Metabolic Maps

• Pyruvate metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.1.2.3

Use Curated BLAST to search for 1.1.2.3

Sequence Analysis Tools

See A0A165KEZ6 at UniProt or InterPro

Protein Sequence (419 amino acids)

>Ac3H11_1767 L-lactate dehydrogenase (EC 1.1.2.3) (Acidovorax sp. GW101-3H11)
MRLSACTDVHTMTTAIDSVSPALSPTPGAPQRSPAVLRRMLSLHDFEDAARRRLPRPIFG
YIAGAAEDNASLRDNREVFGEYAFTTRVLRDVSQRSQAVELFGERYSSPFGIAPMGINAL
STYRGDLVLACAAQRAGIVSVMSGTSLIPMEEVARESPGTWFQAYLPGDQARIDALIDRV
ERAGFRTLVVTVDIPISANRENNIRTGFSTPLRPGLRLAWDGLVRPRWVAGTFVRTLLRH
GMPHFENSFATRGAPIVSSSVLRDFSARDHLSWNHLEAIRRRWKGPLVVKGVLRVEDALQ
ARNLGADGVVLSNHGGRQLDGAVSAMRVLEAVVAAVGPAFPVLIDGGFRRGSDVLKAIAL
GARMVLVGRPFNYAAAVAGEAGVQHAIGLLRDEVDRNLAMLGARACTDLGPGHIVRRHG