Protein Info for Ac3H11_1715 in Acidovorax sp. GW101-3H11

Annotation: Riboflavin kinase (EC 2.7.1.26) / FMN adenylyltransferase (EC 2.7.7.2)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

KEGG orthology group: K11753, riboflavin kinase / FMN adenylyltransferase [EC: 2.7.1.26 2.7.7.2] (inferred from 89% identity to vei:Veis_2108)

Predicted SEED Role

"Riboflavin kinase (EC 2.7.1.26) / FMN adenylyltransferase (EC 2.7.7.2)" in subsystem Riboflavin, FMN and FAD metabolism (EC 2.7.1.26, EC 2.7.7.2)

MetaCyc Pathways

flavin biosynthesis I (bacteria and plants) (8/9 steps found)
flavin salvage (2/2 steps found)
flavin biosynthesis III (fungi) (7/9 steps found)
5,6-dimethylbenzimidazole biosynthesis I (aerobic) (2/3 steps found)
flavin biosynthesis II (archaea) (5/10 steps found)
adenosylcobalamin biosynthesis II (aerobic) (21/33 steps found)
roseoflavin biosynthesis (1/7 steps found)

KEGG Metabolic Maps

Riboflavin metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.1.26 or 2.7.7.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A165KCQ5 at UniProt or InterPro

Protein Sequence (349 amino acids)

>Ac3H11_1715 Riboflavin kinase (EC 2.7.1.26) / FMN adenylyltransferase (EC 2.7.7.2) (Acidovorax sp. GW101-3H11)
MKIFRGFHHPGIANACALTIGNFDGVHRGHQAMLALLNSEAAHRGVESCVLTFEPHPRDY
FAGVHNKPELAPARVGTLRDKLTELARCGVQQTVVLPFDARLAAQSPEAFIDEVLVRGLG
ARYVLVGDDFRFGRQRAGDYAMLDAAGQTKGFDVARMNSYEVHGLRVSSSAVRQALAAGD
MEAAARLLGRPYTISGHVVHGRKLGRELGATAGGAGDGFRTLNLRFAHWKPAASGIFAVL
VHGLAAGPLPGVANLGVRPSLDPNDVNGGRVLLETHCLQWPADLGPEGAYGKIVRVELLH
KLHDELKYDGLDALTQGIAKDCADARAYFASAQAHNHTETRRQTTRDRI