Protein Info for Ac3H11_1638 in Acidovorax sp. GW101-3H11

Annotation: Dienelactone hydrolase family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01738: DLH
  • amino acids 72 to 294 (223 residues), 202.8 bits, E=5.3e-64
• PF07224: Chlorophyllase
  • amino acids 76 to 180 (105 residues), 22.9 bits, E=4.4e-09

Best Hits

Swiss-Prot: 62% identical to DLHH_METEA: Putative carboxymethylenebutenolidase (MexAM1_META1p1735) from Methylobacterium extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1)

KEGG orthology group: K01061, carboxymethylenebutenolidase [EC: 3.1.1.45] (inferred from 82% identity to aaa:Acav_3222)

Predicted SEED Role

"Dienelactone hydrolase family"

MetaCyc Pathways

• 4-chlorocatechol degradation (3/5 steps found)
• 4,5-dichlorocatechol degradation (4/7 steps found)
• 3,4,6-trichlorocatechol degradation (5/9 steps found)
• 3-chlorocatechol degradation I (ortho) (2/5 steps found)
• 3-chlorocatechol degradation II (ortho) (2/5 steps found)
• 3,5-dichlorocatechol degradation (4/8 steps found)
• 1,4-dichlorobenzene degradation (4/9 steps found)

KEGG Metabolic Maps

• 1,4-Dichlorobenzene degradation
• Fluorobenzoate degradation
• gamma-Hexachlorocyclohexane degradation

Isozymes

Compare fitness of predicted isozymes for: 3.1.1.45

Use Curated BLAST to search for 3.1.1.45

Sequence Analysis Tools

See A0A165KAZ6 at UniProt or InterPro

Protein Sequence (298 amino acids)

>Ac3H11_1638 Dienelactone hydrolase family (Acidovorax sp. GW101-3H11)
MLNDDLHTDAHALLPGRTTDAGATRRTALQAALGLGYAAAAAPIMAQTAIATPADGLTAG
EVSFTVNGFKVPAYRAAPAGKTGLPVVLVIQEIFGVHEYIADTCRRFAKAGYLAIAPQLY
ARQGDPSQYTEIAKLMAEVVSKVPDAQVMADLDGAVQWAAANGGDAARVGITGFCWGGRI
TWLYAAHGPVKAGVAWYGRLVGQASELTPKHPVDIAPILKAPVLGLYGEKDTGIPLDTVD
KMKAALAGGSPQAKASEFVVYPDAPHAFHADYRASYRKEAAEDGWKRALAWFKAQGVV