Protein Info for Ac3H11_1505 in Acidovorax sp. GW101-3H11
Annotation: Threonine synthase (EC 4.2.3.1)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 66% identical to THRC_METGL: Threonine synthase (thrC) from Methylobacillus glycogenes
KEGG orthology group: K01733, threonine synthase [EC: 4.2.3.1] (inferred from 85% identity to aaa:Acav_1257)Predicted SEED Role
"Threonine synthase (EC 4.2.3.1)" in subsystem Threonine and Homoserine Biosynthesis (EC 4.2.3.1)
MetaCyc Pathways
- aspartate superpathway (22/25 steps found)
- superpathway of L-isoleucine biosynthesis I (13/13 steps found)
- superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (16/18 steps found)
- superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (13/15 steps found)
- superpathway of L-threonine biosynthesis (6/6 steps found)
- L-threonine biosynthesis (2/2 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 4.2.3.1
Use Curated BLAST to search for 4.2.3.1
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A165K7V5 at UniProt or InterPro
Protein Sequence (481 amino acids)
>Ac3H11_1505 Threonine synthase (EC 4.2.3.1) (Acidovorax sp. GW101-3H11) MKYLSTRGHADRKQFCDILLEGLAPDGGLYLPETYPKITAAALTKLRKAYHEQGYAELAF QILSLYIDDIPAADLKAICAKTYTAEVFGTGEIVPLRHLEDGLWLEALSNGPTLAFKDMA MQLLGNLFEYELGRRGEQLNILGATSGDTGSAAEYAMRGKEGVRVFMTSPHGRMSAFQQA QMFSLQDENIHNIAIEGVFDDCQDIVKAVSNDHAFKAKYKIGTVNSINWARLLAQVVYYF AGYIQATETNNQKVSFTVPSGNFGNICAGHVARMMGLPIAKLVVATNENDVLDEFFRTGV YRVRGSADTHETSSPSMDISKASNFERFIFDLLGRNGQRTKALFSAALQTYGRFDLSADP LFADAAKKYGFESGKSTHADRLATIKDTFERHGVTIDTHTADGVKVAREHHSDAKVPMIV LETALPIKFAETIIEALGHAPERPAKFAGIEDLPKRVHVMPADVEQVKAYIERHCAPAAQ G