Protein Info for Ac3H11_148 in Acidovorax sp. GW101-3H11
Annotation: 3-hydroxybutyrate dehydrogenase (EC 1.1.1.30)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 36% identical to DTHD_MYCS2: D-threitol dehydrogenase (dthD) from Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
KEGG orthology group: K00540, [EC: 1.-.-.-] (inferred from 93% identity to vei:Veis_3982)MetaCyc: 36% identical to D-threitol dehydrogenase (Mycolicibacterium smegmatis)
ERYTHRULOSE-REDUCTASE-RXN [EC: 1.1.1.403]
Predicted SEED Role
"3-hydroxybutyrate dehydrogenase (EC 1.1.1.30)" in subsystem Acetyl-CoA fermentation to Butyrate (EC 1.1.1.30)
MetaCyc Pathways
- ketolysis (3/3 steps found)
- ketogenesis (3/5 steps found)
- D-threitol degradation (1/3 steps found)
KEGG Metabolic Maps
- Alkaloid biosynthesis I
- Butanoate metabolism
- Carotenoid biosynthesis - General
- Insect hormone biosynthesis
- Nucleotide sugars metabolism
- Porphyrin and chlorophyll metabolism
- Puromycin biosynthesis
- Synthesis and degradation of ketone bodies
- Trinitrotoluene degradation
- alpha-Linolenic acid metabolism
Isozymes
Compare fitness of predicted isozymes for: 1.-.-.-, 1.1.1.30
Use Curated BLAST to search for 1.-.-.- or 1.1.1.30 or 1.1.1.403
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A165IXJ7 at UniProt or InterPro
Protein Sequence (260 amino acids)
>Ac3H11_148 3-hydroxybutyrate dehydrogenase (EC 1.1.1.30) (Acidovorax sp. GW101-3H11) MAYSIDLSGRVAFITGASSGLGAQFARTLARAGAGVVLASRRIEKLKELRARIEGEGGDA HVIELDVTDHASIKSAVAHAETEMGSIDILINNSGVSTTQRLQDVTPEDYDFIFDTNVKG AFFVAQEVGKRMLARSRGAAPGSFTGGRIINIASMAGLKVLPQIGAYCMSKAAVVQMTRA MAMEWGKFGINTNAICPGYIDTEINHHHWDTEQGQKLIAMLPRKRVGSPQDLDALLVMLA SDQSHFINGAVIAADDGFAV