Protein Info for Ac3H11_1090 in Acidovorax sp. GW101-3H11

Annotation: Gamma-glutamyltranspeptidase (EC 2.3.2.2)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 594 signal peptide" amino acids 1 to 31 (31 residues), see Phobius details TIGR00066: gamma-glutamyltransferase" amino acids 64 to 585 (522 residues), 644.7 bits, see alignment E=4.8e-198 PF01019: G_glu_transpept" amino acids 79 to 586 (508 residues), 626.4 bits, see alignment E=2.3e-192

Best Hits

Swiss-Prot: 51% identical to GGT_PSEUA: Glutathione hydrolase proenzyme (ggt) from Pseudomonas sp. (strain A14)

KEGG orthology group: K00681, gamma-glutamyltranspeptidase [EC: 2.3.2.2] (inferred from 83% identity to adn:Alide_3091)

Predicted SEED Role

"Gamma-glutamyltranspeptidase (EC 2.3.2.2)" in subsystem Glutathione: Biosynthesis and gamma-glutamyl cycle or Utilization of glutathione as a sulphur source (EC 2.3.2.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.3.2.2

Use Curated BLAST to search for 2.3.2.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A165J5Q8 at UniProt or InterPro

Protein Sequence (594 amino acids)

>Ac3H11_1090 Gamma-glutamyltranspeptidase (EC 2.3.2.2) (Acidovorax sp. GW101-3H11)
MNIRHTLLASSLALALASLTACGSAPTTAAAPAPAVQQTAAAQAASAAYDFSMDVFHPVV
ARNGMVATEQELASQIGLDILKAGGNAVDAAVGIGFALAVALPNAGNLGGGGFMVVHDAK
TGKSVALDFREVAPSKATRDMYLDAKGNVVDGKSLYTHYAVGVPGTVAGMEHALKTWGTL
PLSRVIAPAIELADKGFPVSETLAKILQQEKKNMGNWPATQAIFWKNGEPLKVGDPLVQK
DLAQSMRLIGQQGAKAFYEGEIAQKIAAEMAPHAGAISLQDLREYKVAERVPTRGTYRGY
EIVTMPPPSSGGPHLVQILNMLEPLPLAQWGPNSAQTIHYMAESSKLAYADRSEYLGDPD
FVKIPLKGLTSKRYAESLAKGIDANRARPAKEIKPGQPQPYESDQTTHYSVVDKAGNAVA
VTYTLNTNFGSGIVAKGTGILLNNEMDDFSAKPGVANAYGLVGGDANAVAAKKRPLSSMT
PTLVLKDGKPTLVTGSPGGARIITTVLQTVVNTIDFGMNPAEAAAAPRVHHQWTPDELRV
EKGLSPDTLALLKQRGHNIAVKPSMGRTQTIQIRGGALYGYSDPRNPDGKTLGY