Protein Info for Ac3H11_1087 in Acidovorax sp. GW101-3H11

Annotation: Hydroxypyruvate isomerase (EC 5.3.1.22)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR03234: hydroxypyruvate isomerase
  • amino acids 2 to 253 (252 residues), 388.5 bits, E=6e-121
• PF01261: AP_endonuc_2
  • amino acids 21 to 253 (233 residues), 180.5 bits, E=2.4e-57

Best Hits

Swiss-Prot: 59% identical to HYI_ECOLI: Hydroxypyruvate isomerase (hyi) from Escherichia coli (strain K12)

KEGG orthology group: K01816, hydroxypyruvate isomerase [EC: 5.3.1.22] (inferred from 83% identity to del:DelCs14_4566)

MetaCyc: 59% identical to hydroxypyruvate isomerase (Escherichia coli K-12 substr. MG1655)
Hydroxypyruvate isomerase. [EC: 5.3.1.22]

Predicted SEED Role

"Hydroxypyruvate isomerase (EC 5.3.1.22)" (EC 5.3.1.22)

KEGG Metabolic Maps

• Glyoxylate and dicarboxylate metabolism

Isozymes

Compare fitness of predicted isozymes for: 5.3.1.22

Use Curated BLAST to search for 5.3.1.22

Sequence Analysis Tools

See A0A165J5N9 at UniProt or InterPro

Protein Sequence (259 amino acids)

>Ac3H11_1087 Hydroxypyruvate isomerase (EC 5.3.1.22) (Acidovorax sp. GW101-3H11)
MPRFAANLSMLFTEVPFLDRFERAARTGFEAVEFLFPYEFPAEEIRARIDKHQLQIVLHN
LPAGDWAAGERGIACDPARIVEFRAGVALAITYAQALGVPQLNCLAGKAPAGVDAAVLRR
TLVDNLRFAATELRAAGLRLLIEPINPFDIPGFYLTRTDQALDILDEVDASNAFVQYDIY
HAQRTEGEIAATLQKHLPRIGHVQLADNPGRNEPGTGEINYRYLFAHLDRIGYDGWVGCE
YRPARTTEIGLGWRTALTA