Protein Info for AZOBR_RS16025 in Azospirillum brasilense Sp245

Annotation: threonine synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00260: threonine synthase
  • amino acids 68 to 384 (317 residues), 169 bits, E=7.8e-54
• PF00291: PALP
  • amino acids 83 to 387 (305 residues), 245.2 bits, E=4.8e-77

Best Hits

KEGG orthology group: K01733, threonine synthase [EC: 4.2.3.1] (inferred from 91% identity to azl:AZL_b02460)

Predicted SEED Role

"Threonine synthase (EC 4.2.3.1)" in subsystem Threonine and Homoserine Biosynthesis (EC 4.2.3.1)

MetaCyc Pathways

• aspartate superpathway (23/25 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (17/18 steps found)
• superpathway of L-isoleucine biosynthesis I (13/13 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (13/15 steps found)
• superpathway of L-threonine biosynthesis (6/6 steps found)
• L-threonine biosynthesis (2/2 steps found)

KEGG Metabolic Maps

• Glycine, serine and threonine metabolism
• Vitamin B6 metabolism

Isozymes

Compare fitness of predicted isozymes for: 4.2.3.1

Use Curated BLAST to search for 4.2.3.1

Sequence Analysis Tools

See G8AR51 at UniProt or InterPro

Protein Sequence (413 amino acids)

>AZOBR_RS16025 threonine synthase (Azospirillum brasilense Sp245)
VPFDSNLTTERPTFVTHLECAYTGERYEADTVHNLSKAGKPLLVRYDLEGVRGALTKDAL
AERPQDLWRYRELLPVRRVQDIVSLGEAVTPLVALPKLAAKLGAAELLVKDEGRLPTGSF
KARGLVMAVSMAKAFGIKHMAMPTNGNAGAALAAYATRAGIKTTIFCPEDTPEVNVSEIE
LQGATVYRVNGLIDDCGKIVGEGKAKAGWFDVSTLKEPYRIEGKKTMGLELAEQLGWEVP
DVIFYPTGGGTGLIGMWKAFAELEAIGFIGSKRPRMVAVQAAGCAPMVRAYEAGEEHAPR
WPDAHTIASGIRVPQAVGDFLILRAVRESGGFAVAVPDEAIQAALDEAAREEGFLLCPEG
AATYAAYKQALGDGRVGRDERAVLFNCATGLKYPLPPVHRTLDRHQPIDYSVF