Protein Info for AZOBR_RS10460 in Azospirillum brasilense Sp245

Annotation: glycine dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 446 PF02347: GDC-P" amino acids 1 to 438 (438 residues), 400 bits, see alignment E=6.6e-124

Best Hits

Swiss-Prot: 74% identical to GCSPA_RHOCS: Probable glycine dehydrogenase (decarboxylating) subunit 1 (gcvPA) from Rhodospirillum centenum (strain ATCC 51521 / SW)

KEGG orthology group: K00282, glycine dehydrogenase subunit 1 [EC: 1.4.4.2] (inferred from 85% identity to azl:AZL_015860)

Predicted SEED Role

"Glycine dehydrogenase [decarboxylating] (glycine cleavage system P1 protein) (EC 1.4.4.2)" in subsystem Glycine and Serine Utilization or Glycine cleavage system or Photorespiration (oxidative C2 cycle) (EC 1.4.4.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.4.4.2

Use Curated BLAST to search for 1.4.4.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (446 amino acids)

>AZOBR_RS10460 glycine dehydrogenase (Azospirillum brasilense Sp245)
MRYLPLTEADRRSMLEAIGVPSVDELFRDVPEAARLSGPIEGLSNHMGELEVDRALSAMA
GKNLPAGSVPSFLGAGAYRHHIPATVDHLVQRGEFLTAYTPYQPEVSQGTLQVLFEFQTQ
VSLLTGMDVANASMYDGATACAEAVMMANRVTRRKKAVLSGGLHPHYRDTTTTDARFIGF
ETVVMPPAPTGGEDLLAAVDGDTSCVVVQNPDVFGHVRDYTELGKACQAKGALLIVVVTE
AVSLGLLTPPGDMGADIVAAEGQSLGNALNFGGPYVGLFAVKEKLVRQMPGRLCGQTVDA
DGRRGFVLTLSTREQHIRREKATSNICTNSGLCALAFSIHLSLLGEEGFTRLAEINHAKA
VQLADKLAAVTGVEIVNDSFFNEFTVKLPKPAAEVVEALAQRGILGGVPASRLFGGGLDD
LLIVAATETNTESDMDAFATALAEVL