Protein Info for AO356_18140 in Pseudomonas fluorescens FW300-N2C3

Annotation: copper oxidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 602 signal peptide" amino acids 1 to 33 (33 residues), see Phobius details TIGR01480: copper-resistance protein, CopA family" amino acids 2 to 601 (600 residues), 1003.6 bits, see alignment E=2.9e-306 TIGR01409: Tat (twin-arginine translocation) pathway signal sequence" amino acids 5 to 32 (28 residues), 21.5 bits, see alignment (E = 2.1e-08) PF07732: Cu-oxidase_3" amino acids 53 to 163 (111 residues), 131.5 bits, see alignment E=2.6e-42 amino acids 492 to 600 (109 residues), 23.6 bits, see alignment E=6.8e-09 PF00394: Cu-oxidase" amino acids 172 to 346 (175 residues), 91.9 bits, see alignment E=7.2e-30 PF07731: Cu-oxidase_2" amino acids 485 to 601 (117 residues), 98.7 bits, see alignment E=3.8e-32

Best Hits

Swiss-Prot: 77% identical to COPA_PSEUB: Copper resistance protein A (copA) from Pseudomonas syringae pv. tomato

KEGG orthology group: None (inferred from 95% identity to pba:PSEBR_a4426)

Predicted SEED Role

"Multicopper oxidase" in subsystem Copper homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0N9WAJ7 at UniProt or InterPro

Protein Sequence (602 amino acids)

>AO356_18140 copper oxidase (Pseudomonas fluorescens FW300-N2C3)
MQTKTSRRTFVKGLTAGGILGGLGLWRAPVWAVTGPGQPNVLSGTEFDLFIGESPVNFTG
NPRTAQTINGGIPGPLLRWREGDTVTLRVRNRLQDTTSIHWHGILLPANMDGVPGLSFKG
IEPGGLYVYQFKVRQNGTYWYHSHSGFQEQSGVYGPLVIDAREPEPFQYERDYVVMLTDW
TDEDPANILRKLKKQSDYYNYNKRTVGDFIDDVGKNGWASTVADRKMWAEMKMNPTDLAD
VSGATYTYLMNGQAPDMNWTGLFKPGERLRLRFINGSSMSYFDVRIPGLKMTVVASDGQY
VKPVSVDEFRIAVAETYDVIIEPTQEAYTLFAQSMDRTGYARGTLATRAGLSAPVPPLDP
RPLVTMDDMGMGGMDHGGMGQMNGMDHGSMQGMAGMDDSSMQGMDHSQMQGMGDMAGMDH
GAMQGMDSMLAHPDTEKDNPLVDMQAMSVKPKLDDPGMGLRDNGRKVLTYSDLRSTFPDP
DGREPGRTIELHLTGHMEKFVWSFNGVKFADAAPLLLKYGERLRIVLINDTMMTHPIHLH
GMWSDLEDENNQFMVRKHTIDVPPGARRSYRVTADALGRWAYHCHLLFHMEMGMFREVRV
QE