Protein Info for AO356_09635 in Pseudomonas fluorescens FW300-N2C3

Updated annotation (from data): histidine utilization regulatory protein hutD
Rationale: Specifically important for: L-Histidine. Believed to prevent overexpression of the hut operon (not an enzyme) (PMC:1950622)
Original annotation: hypothetical protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 189 PF05962: HutD" amino acids 9 to 182 (174 residues), 182.9 bits, see alignment E=3.4e-58

Best Hits

KEGG orthology group: K09975, hypothetical protein (inferred from 88% identity to pba:PSEBR_a377)

Predicted SEED Role

"Conserved hypothetical protein (perhaps related to histidine degradation)" in subsystem Histidine Degradation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0N7H1W3 at UniProt or InterPro

Protein Sequence (189 amino acids)

>AO356_09635 histidine utilization regulatory protein hutD (Pseudomonas fluorescens FW300-N2C3)
MSQLKVLRAADYPRMPWKNGGGSTEEITRDAGTGLEGFGWRLSIADIGESGGFSTFAGYE
RIISVLQGDGMTLNVDGQATGPLRPLDPFAFSGESHVHCTLLGGPIRDFNLIYAPQRYRA
RLQWVGGQQRFFSEAETLLVFSAAPGLTIRIGESAVILGLYDCLQLSGNTGLLDITSHGQ
CCVIELTAR