Protein Info for AO356_03480 in Pseudomonas fluorescens FW300-N2C3

Annotation: methylthioribose-1-phosphate isomerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00512: S-methyl-5-thioribose-1-phosphate isomerase
  • amino acids 12 to 341 (330 residues), 433.2 bits, E=5.7e-134
• TIGR00524: eIF-2B alpha/beta/delta-related uncharacterized proteins
  • amino acids 38 to 341 (304 residues), 325 bits, E=4.3e-101
• PF01008: IF-2B
  • amino acids 53 to 341 (289 residues), 243.9 bits, E=1e-76

Best Hits

Swiss-Prot: 86% identical to MTNA_PSEPF: Methylthioribose-1-phosphate isomerase (mtnA) from Pseudomonas fluorescens (strain Pf0-1)

KEGG orthology group: K08963, methylthioribose-1-phosphate isomerase [EC: 5.3.1.23] (inferred from 91% identity to pba:PSEBR_a1547)

Predicted SEED Role

"Methylthioribose-1-phosphate isomerase (EC 5.3.1.23)" in subsystem Methionine Salvage (EC 5.3.1.23)

MetaCyc Pathways

• 5'-deoxyadenosine degradation I (1/3 steps found)
• S-methyl-5-thio-α-D-ribose 1-phosphate degradation II (2/5 steps found)
• S-methyl-5-thio-α-D-ribose 1-phosphate degradation III (2/5 steps found)
• 5'-deoxyadenosine degradation II (1/4 steps found)
• L-methionine salvage cycle III (5/11 steps found)
• S-methyl-5-thio-α-D-ribose 1-phosphate degradation I (2/7 steps found)
• L-methionine salvage cycle I (bacteria and plants) (4/12 steps found)
• L-methionine salvage cycle II (plants) (3/11 steps found)

KEGG Metabolic Maps

• Methionine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.3.1.23

Sequence Analysis Tools

See A0A0N9WUD4 at UniProt or InterPro

Protein Sequence (358 amino acids)

>AO356_03480 methylthioribose-1-phosphate isomerase (Pseudomonas fluorescens FW300-N2C3)
MRDRLLAAEKVKAIDWRDGVLYLLDQRILPFEESWIACTRVADVAEAIGSMAVRGAPVIG
ISAAYGVVLAARARMAEGGDWQAALEADFALLAEARPTAANLFWALDRMRDRLGRLKEHA
EPLAVLEAEAIAIHVSDREANLTMAQLGVDLIRKHQGNAQAILTHCNTGALATGGFGTAL
GVIRGAYIEGMVERVYADETRPWLQGSRLTAWELAREGIPVTLNADSAAAHIMKTKGVTW
VIVGADCIAANGDVANKIGTYQMAVCAMHHGVRFMVVAPSSIIDMSLASGEDIPAEECDG
RELLEIGGRELDAQVGAFNPVFDITPADLIDVIVTEKGIVERPDTAKLAQLMCRKRLH