Protein Info for AO353_22400 in Pseudomonas fluorescens FW300-N2E3

Annotation: pyrroloquinoline quinone biosynthesis protein PqqC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 TIGR02111: coenzyme PQQ biosynthesis protein C" amino acids 7 to 241 (235 residues), 401.1 bits, see alignment E=7.4e-125 PF03070: TENA_THI-4" amino acids 13 to 222 (210 residues), 220.4 bits, see alignment E=1.2e-69

Best Hits

Swiss-Prot: 86% identical to PQQC_PSEE4: Pyrroloquinoline-quinone synthase (pqqC) from Pseudomonas entomophila (strain L48)

KEGG orthology group: K06137, pyrroloquinoline-quinone synthase [EC: 1.3.3.11] (inferred from 86% identity to pfo:Pfl01_5159)

MetaCyc: 74% identical to pyrroloquinoline-quinone synthase monomer (Klebsiella pneumoniae)
Pyrroloquinoline-quinone synthase. [EC: 1.3.3.11]

Predicted SEED Role

"Pyrroloquinoline-quinone synthase (EC 1.3.3.11)" (EC 1.3.3.11)

MetaCyc Pathways

Isozymes

Compare fitness of predicted isozymes for: 1.3.3.11

Use Curated BLAST to search for 1.3.3.11

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0N9W9A2 at UniProt or InterPro

Protein Sequence (250 amino acids)

>AO353_22400 pyrroloquinoline quinone biosynthesis protein PqqC (Pseudomonas fluorescens FW300-N2E3)
MTDTPLAPAEFEQALRAKGAYYHIHHPFHQAMYAGRATREQIQGWVANRFYYQLNIPLKD
AAILANCPDREVRREWLQRLVDHDGVPGSEGGIEAWLRLGEAVGIARERMLSQEMVLPGV
RFAVDAYVNFARRACWQEAASSSLTELFAPQIHQSRLDAWPQHYPWIDPAGYQYFRTRLS
QARRDVEHGLRITLAHYVTREGQQRMLEILQFKLDVLWSMLDAMSMAYELERPPYHSVTR
EAVWHRGIIL