Protein Info for AO353_22210 in Pseudomonas fluorescens FW300-N2E3

Annotation: copper oxidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 616 signal peptide" amino acids 1 to 33 (33 residues), see Phobius details TIGR01480: copper-resistance protein, CopA family" amino acids 4 to 614 (611 residues), 989.3 bits, see alignment E=6.2e-302 TIGR01409: Tat (twin-arginine translocation) pathway signal sequence" amino acids 5 to 32 (28 residues), 23.6 bits, see alignment (E = 4.9e-09) PF07732: Cu-oxidase_3" amino acids 53 to 163 (111 residues), 131.3 bits, see alignment E=2.9e-42 amino acids 510 to 614 (105 residues), 26.9 bits, see alignment E=6.4e-10 PF00394: Cu-oxidase" amino acids 172 to 347 (176 residues), 90.2 bits, see alignment E=2.4e-29 PF07731: Cu-oxidase_2" amino acids 498 to 615 (118 residues), 100.7 bits, see alignment E=9e-33

Best Hits

Swiss-Prot: 78% identical to COPA_PSEUB: Copper resistance protein A (copA) from Pseudomonas syringae pv. tomato

KEGG orthology group: None (inferred from 80% identity to ppf:Pput_0015)

Predicted SEED Role

"Multicopper oxidase" in subsystem Copper homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0N9WNX2 at UniProt or InterPro

Protein Sequence (616 amino acids)

>AO353_22210 copper oxidase (Pseudomonas fluorescens FW300-N2E3)
MHSKTSRRTFVKGLAAGGILGGLGLWRTPVWAVTSPGLPSVLSGNEFDLFIGETPVNITG
SPRTAMTINGTLPGPLLRWREGETVTLRVKNRLDQDTSIHWHGIILPANMDGVPGLSFHG
IAPDGMYEYTFKVHQNGTYWYHSHSGFQEQVGVYGPIVIDSKEPEPFQYHRDYVVMLTDW
TDEDPGRVMAKLKKQSDYYNHRKRTAGDFIDDVSKQGWSAAVADRKMWAEMKMNPTDLAD
VSGDTYTYLMNGQAPNGNWTGIFKPGEKLRLRFINGSAMSYFDVRIPGLKMTVVAADGQH
VNPVSVDEFRIAVAETYDVIVEPSSQEAYTIFAQSMDRTGYARGTLAVREGLKAPVPTID
PRPLLTMDDMGMGGMAGMDHGSMGGDMSGMTAMDHGNMTGMDQGGMTGMDNGDMSSMAGM
DHSKMAGMDHGDMSGMAGMGGEMQTHPASETNNPLVDMQAMSPTPKLNDPGIGLRNNGRR
VLTYSDLKSTFQDPDGREPNRTIELHLTGHMEKFSWSFNGIKFSDAEPLRLKYGERLRIT
LVNDTMMTHPIHLHGMWSDLEDENGKFMVRKHTIDMPPGTRRSYRVTADALGRWAYHCHL
LFHMEMGMFREVRVDE