Protein Info for AO353_21490 in Pseudomonas fluorescens FW300-N2E3

Annotation: 1-carboxy-3-chloro-3,4-dihydroxycyclo hexa-1,5-diene dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01408: GFO_IDH_MocA
  • amino acids 5 to 130 (126 residues), 96.1 bits, E=2.5e-31
• PF02894: GFO_IDH_MocA_C
  • amino acids 142 to 368 (227 residues), 109 bits, E=3.1e-35

Best Hits

KEGG orthology group: None (inferred from 84% identity to pba:PSEBR_a3329)

Predicted SEED Role

"Myo-inositol 2-dehydrogenase (EC 1.1.1.18)" in subsystem Inositol catabolism (EC 1.1.1.18)

MetaCyc Pathways

• myo-inositol degradation I (7/7 steps found)
• myo-, chiro- and scyllo-inositol degradation (7/10 steps found)
• myo-inositol degradation II (1/5 steps found)
• streptomycin biosynthesis (2/18 steps found)

KEGG Metabolic Maps

• Inositol phosphate metabolism
• Streptomycin biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.18

Use Curated BLAST to search for 1.1.1.18

Sequence Analysis Tools

See A0A0N9WZ58 at UniProt or InterPro

Protein Sequence (371 amino acids)

>AO353_21490 1-carboxy-3-chloro-3,4-dihydroxycyclo hexa-1,5-diene dehydrogenase (Pseudomonas fluorescens FW300-N2E3)
MRELGIGLIGTGFMGRAHALAFRNVSAAFELPFTLRLAALADADPARAQACATAWGFEQA
HSDWQQLIDDPKVNLIAITTPNHLHYPMAMAAIAAGKPLYCEKPLAVSLEQASAMHLAAK
TAGVVTRVGYNYQHNPIIGLARELIRNGELGEIISFQGEFSEDFMADPNSPWSWRCEAEH
AGGALADLGSHLLAMARYLVGDVEAVCADTQTVHRQRPATAGSLEQRSIAVDDQAHALLR
FANGARGTFSSSWLKHGYKNHLSFEISGTQGTLAFDQERLNELRLCRAGQDGFQRLLAGP
NLPGYAAFSPAPGHQLGYNELKTLEVHALIMALAGQGQDGTDFEEAWEVERLAAAIRLAA
REQRWVNIREV