Protein Info for AO353_17295 in Pseudomonas fluorescens FW300-N2E3

Annotation: multidrug transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1055 transmembrane" amino acids 10 to 28 (19 residues), see Phobius details amino acids 340 to 359 (20 residues), see Phobius details amino acids 366 to 388 (23 residues), see Phobius details amino acids 395 to 414 (20 residues), see Phobius details amino acids 438 to 459 (22 residues), see Phobius details amino acids 471 to 494 (24 residues), see Phobius details amino acids 539 to 557 (19 residues), see Phobius details amino acids 877 to 895 (19 residues), see Phobius details amino acids 902 to 922 (21 residues), see Phobius details amino acids 929 to 952 (24 residues), see Phobius details amino acids 976 to 997 (22 residues), see Phobius details amino acids 1005 to 1029 (25 residues), see Phobius details PF00873: ACR_tran" amino acids 1 to 1031 (1031 residues), 1357.3 bits, see alignment E=0 TIGR00915: RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family" amino acids 1 to 1048 (1048 residues), 1838.2 bits, see alignment E=0 PF02460: Patched" amino acids 339 to 495 (157 residues), 23.5 bits, see alignment E=3.2e-09 PF03176: MMPL" amino acids 343 to 513 (171 residues), 37.2 bits, see alignment E=3.4e-13

Best Hits

Swiss-Prot: 86% identical to TTGB_PSEPK: Probable efflux pump membrane transporter TtgB (ttgB) from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)

KEGG orthology group: K03296, hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family (inferred from 65% identity to abo:ABO_0964)

MetaCyc: 67% identical to multidrug efflux pump RND permease AcrB (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-354; TRANS-RXN-355; TRANS-RXN-356; TRANS-RXN-357; TRANS-RXN-359; TRANS-RXN0-592

Predicted SEED Role

"RND efflux system, inner membrane transporter CmeB" in subsystem Multidrug Resistance Efflux Pumps or Multidrug efflux pump in Campylobacter jejuni (CmeABC operon)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0N9WEA5 at UniProt or InterPro

Protein Sequence (1055 amino acids)

>AO353_17295 multidrug transporter (Pseudomonas fluorescens FW300-N2E3)
MSKFFIDRPIFAWVIALVIMLVGALSILKLPINQYPSIAPPAIAISVTYPGASAQTVQDT
VVQVIEQQLNGIDNLRYVSSESNSDGSMTITATFEQGTNSDTAQVQVQNKLNLATPLLPQ
EVQQQGIRVTKAVKNFLMVIGVVSRDGSMTKDDLSNYIVSNMQDPISRTAGVGDFQVFGA
QYAMRIWLDPAKLNNFNLTPVDVKTAIAAQNVQVSSGQLGGLPALPGQQLNATIIGKTRL
QTAEQFKEILLRVNKDGSQVRLSDVADVGLGGENYSISAQFNGSPASGLAVKLANGANAL
DTAKALRKTIDNLKPFFPEGMEVVFPYDTTPVVTESIKGVVETLVEAIVLVFLVMFLFLQ
NFRATVITTMTVPVVLLGTFGILAAFGFSINTLTMFGMVLAIGLLVDDAIVVVENVERVM
SEEGLSPKEATKKSMGQIQGALVGIALVLSAVLLPMAFFSGSTGVIYKQFSITIVSAMAL
SVLVALIFTPALCATMLKAIPKGEHGTPKRGFFGWFNRNFDRSVRSYERGVGNMLKHKAP
YLLAYIIIVVGMIWLFTRIPTAFLPEEDQGVLFAQVQTPAGSTSQRTQVVVDEMREFLLR
PGKDGGEGDAVNSVFTVTGFNFAGRGQSSGMAFIMLRPWAERNADNSVFKVAARAQQHFF
TFRDAMVFAFAPPAVLELGNATGFDVFLQDRAGIGHDKLMAARNQFLGMAAQSKVLSQVR
PNGLNDEPQYQLEIDDEKASALGITMTDINNTLSIALGSSYVNDFIDRGRVKKVYVQGQP
GARMSPEDLKKWYVRNSQGAMVPFSAFAKGEWIYGSPKLARYNGVEAVEILGSPAPGYST
GEAMAEVEALAQKLPAGVGISWTGLSYEERLSGSQAPALYALSLLMVFLCLAALYESWSI
PIAVMLVVPLGIIGALLATSLRGLSNDVYFQVGLLTTIGLAAKNAILIVEFAKELHEQGR
SLSDAAIEACRMRLRPIIMTSLAFVLGVVPLAISTGAGSGSQHAIGTGVIGGMLTATVLA
IFWVPLFFVTVSSMGQRKTADQDDVAIETSKEAGQ