Protein Info for AO353_13330 in Pseudomonas fluorescens FW300-N2E3

Annotation: aldehyde dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 19 to 478 (460 residues), 432 bits, E=1.2e-133

Best Hits

Swiss-Prot: 51% identical to AL7B4_ARATH: Aldehyde dehydrogenase family 7 member B4 (ALDH7B4) from Arabidopsis thaliana

KEGG orthology group: K00128, aldehyde dehydrogenase (NAD+) [EC: 1.2.1.3] (inferred from 96% identity to pba:PSEBR_a568)

MetaCyc: 81% identical to L-aminoadipate-semialdehyde dehydrogenase (Pseudomonas putida)
L-aminoadipate-semialdehyde dehydrogenase. [EC: 1.2.1.31]

Predicted SEED Role

"L-pipecolate dehydrogenase (EC 1.5.99.3)" in subsystem Lysine degradation (EC 1.5.99.3)

MetaCyc Pathways

• ethanol degradation II (3/3 steps found)
• ethanol degradation IV (3/3 steps found)
• mitochondrial NADPH production (yeast) (4/5 steps found)
• octane oxidation (4/5 steps found)
• superpathway of NAD/NADP - NADH/NADPH interconversion (yeast) (6/8 steps found)
• phytol degradation (3/4 steps found)
• ethanol degradation III (2/3 steps found)
• hypotaurine degradation (2/3 steps found)
• fatty acid α-oxidation I (plants) (2/4 steps found)
• putrescine degradation III (2/4 steps found)
• histamine degradation (1/3 steps found)
• 3-methyl-branched fatty acid α-oxidation (3/6 steps found)
• L-lysine degradation V (5/9 steps found)
• L-tryptophan degradation X (mammalian, via tryptamine) (1/4 steps found)
• serotonin degradation (3/7 steps found)
• dopamine degradation (1/5 steps found)
• ceramide degradation by α-oxidation (2/7 steps found)
• sphingosine and sphingosine-1-phosphate metabolism (4/10 steps found)
• alkane oxidation (1/6 steps found)
• L-lysine degradation II (L-pipecolate pathway) (3/9 steps found)
• limonene degradation IV (anaerobic) (1/7 steps found)
• aromatic biogenic amine degradation (bacteria) (1/8 steps found)
• noradrenaline and adrenaline degradation (4/13 steps found)
• ceramide and sphingolipid recycling and degradation (yeast) (4/16 steps found)
• superpathway of L-lysine degradation (18/43 steps found)

KEGG Metabolic Maps

• 1,2-Dichloroethane degradation
• 3-Chloroacrylic acid degradation
• Arginine and proline metabolism
• Ascorbate and aldarate metabolism
• Butanoate metabolism
• Fatty acid metabolism
• Glycerolipid metabolism
• Glycolysis / Gluconeogenesis
• Histidine metabolism
• Limonene and pinene degradation
• Lysine biosynthesis
• Lysine degradation
• Propanoate metabolism
• Pyruvate metabolism
• Tryptophan metabolism
• Urea cycle and metabolism of amino groups
• Valine, leucine and isoleucine degradation
• beta-Alanine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.3

Use Curated BLAST to search for 1.2.1.3 or 1.2.1.31 or 1.5.99.3

Sequence Analysis Tools

See A0A0N7H033 at UniProt or InterPro

Protein Sequence (496 amino acids)

>AO353_13330 aldehyde dehydrogenase (Pseudomonas fluorescens FW300-N2E3)
MVAALLDRLGVNPALYQNGKQPVHSPIDGSHIASVNWEGAAEVEQQVSRAEHAFDLWRKV
PAPRRGELVRQFGEVLREYKADLGELVSWEAGKITQEGLGEVQEMIDICDFAVGLSRQLY
GLTIASERPGHHMRESWHPLGVVGVISAFNFPVAVWAWNTTLALVCGNSVIWKPSEKTPL
TALACQALFERVLKNFSDAPEYLSQVIIGGRDAGEALVDDPRVALISATGSTRMGREVAP
KIAARFARSILELGGNNAMILGPSADLDMAVRAILFSAVGTAGQRCTTLRRLIAHESVKE
EIVTRLKAAYSKVRIGHPLEGNLVGPLIDKHSFDNMQDALEQALSEGGRVFGGQRQLEDK
FPNAYYVSPAIVEMPEQSDVVRSETFAPILYVVGYKDFAEALRLNNAVPQGLSSCIFTTD
VREAEQFMSAVGSDCGIANVNIGPSGAEIGGAFGGEKETGGGRESGSDAWRGYMRRQTNT
VNYSLELPLAQGITFD