Protein Info for AO353_00770 in Pseudomonas fluorescens FW300-N2E3

Annotation: nucleotide cyclase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 799 transmembrane" amino acids 20 to 43 (24 residues), see Phobius details amino acids 315 to 338 (24 residues), see Phobius details PF03924: CHASE" amino acids 88 to 274 (187 residues), 126.6 bits, see alignment E=3.3e-40 PF00989: PAS" amino acids 376 to 495 (120 residues), 31.3 bits, see alignment E=5.2e-11 TIGR00229: PAS domain S-box protein" amino acids 377 to 505 (129 residues), 37.7 bits, see alignment E=2e-13 PF13426: PAS_9" amino acids 381 to 497 (117 residues), 26.3 bits, see alignment E=2.3e-09 PF08447: PAS_3" amino acids 536 to 610 (75 residues), 35.9 bits, see alignment E=2.2e-12 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 637 to 796 (160 residues), 155.1 bits, see alignment E=1.4e-49 PF00990: GGDEF" amino acids 641 to 793 (153 residues), 148.8 bits, see alignment E=3.6e-47

Best Hits

KEGG orthology group: None (inferred from 70% identity to pba:PSEBR_a1695)

Predicted SEED Role

"CHASE domain/PAS domain protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0N9VZX0 at UniProt or InterPro

Protein Sequence (799 amino acids)

>AO353_00770 nucleotide cyclase (Pseudomonas fluorescens FW300-N2E3)
MPLHAVRPKILGLISEDVSAWLVALLVLLAGGVLTGLLAWASFNAQHQQMAQRFQMLVNE
RKSRITERFDDQEQRLDSLRRFFVNSESVSREEFDGFTKALLHRTQAYAWAPLVARSERS
AFEQRVREQGKAGFSIRDLTPSAELQPAALRDEYAPVLYSQALGSKAAPLGFDMLSEPTR
RATLERARTLNAMAVSEPTLLIGVDPEYAHGVLLVEPVLRDTAASAHDATPLGYVLAVIS
MRQLVVDGFPLPGQDNLVVQIRDRAQGAQAQALYESTNPVANQPLHYSSMLRLGEHVYDL
DIRTSRVFEHATHSAVASLIVMGTLLSVLLSALLYILVSQRQRALALVEQRTRELRLREQ
ELSGAHGQLRGVLAAATQVAVIATNLRGVITTFNAGAEHMLGYRSVDVLGQATLESLHLP
AELEARAVELSQRYCKPVPGCQAMLVEGGKAGGHEAREWTLVRQDGSHLTVNMLATAVLD
EQGLWVGNLAICIDITERKRVHEALAARDLLLKKLSAHVPGGIYQFKMAADGLFSVIYAS
DGIRDIYEIDPDVLQQNAEAIFERIHPQDVARVRASIRVSSLKLSPWREEYRVQLPVRGL
RWVRGEATPEELPGGGVLWHGYISDISDLKRVEEELRALSVTDSLTGIHNRRYFQERLTM
EMARVERGVGDLAVIMLDIDHFKRINDVYGHAAGDRVLQAICQRIRQRLRRTDVFCRLGG
EEFMVLCPDTDGQHAHTLAVELWQSLRNTPIEGLGTVTASFGIASWRSGEGADALLLRAD
SGVYAAKQAGRDRVEMELV