Protein Info for ABZR87_RS23585 in Ralstonia sp. UNC404CL21Col

Annotation: NCS2 family permease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 434 transmembrane" amino acids 21 to 41 (21 residues), see Phobius details amino acids 51 to 71 (21 residues), see Phobius details amino acids 75 to 91 (17 residues), see Phobius details amino acids 98 to 121 (24 residues), see Phobius details amino acids 133 to 157 (25 residues), see Phobius details amino acids 169 to 187 (19 residues), see Phobius details amino acids 194 to 215 (22 residues), see Phobius details amino acids 234 to 255 (22 residues), see Phobius details amino acids 283 to 305 (23 residues), see Phobius details amino acids 317 to 335 (19 residues), see Phobius details amino acids 341 to 360 (20 residues), see Phobius details amino acids 379 to 402 (24 residues), see Phobius details amino acids 413 to 431 (19 residues), see Phobius details PF00860: Xan_ur_permease" amino acids 20 to 390 (371 residues), 193.1 bits, see alignment E=3.3e-61

Best Hits

Swiss-Prot: 50% identical to ADEP_ECOLI: Adenine permease AdeP (adeP) from Escherichia coli (strain K12)

KEGG orthology group: K06901, putative MFS transporter, AGZA family, xanthine/uracil permease (inferred from 96% identity to rpf:Rpic12D_3892)

MetaCyc: 50% identical to adenine:H+ symporter (Escherichia coli K-12 substr. MG1655)
TRANS-RXN0-447

Predicted SEED Role

"Xanthine/uracil/thiamine/ascorbate permease family protein" in subsystem Purine Utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (434 amino acids)

>ABZR87_RS23585 NCS2 family permease (Ralstonia sp. UNC404CL21Col)
MTWIARTFKLEEHQTNVRTEVLAGLTTFLTMAYIIFVNPNILADAGMPHDAVFVATCIAA
AIGTIIMGMYANYPIAMAPGMGLNAYFAYAVVKGMGFTWQAALGAVFISGCLFLLVSVFR
IREMIVNGIPHSIRVAITAGIGLFLGIVSLRGAGLIVGNPATLVTLGDVHQPSVILAVIG
FFVIVALDHLRVKGAILIGILAVTAASFFFAGNTFHGVVSMPPSLAPTLMQLDIMGALSV
GILNVVLVFFLVELFDATGTLMGVANRAGLLKQGKMDRLNKALLADSTAIMAGSLLGTSS
TTAYIESASGVQAGGRTGLTALTVAALFLLCLFFSPLAGVVPAYATAPALLYVSCLMLRE
LVDLNWEDTTEAVPAVLTALMMPFTYSIANGVAFGFITYAGLKLFTGRMREVPVIVWIIS
AVFLFRFFYLSGGH