Protein Info for ABZR87_RS23515 in Ralstonia sp. UNC404CL21Col

Annotation: sigma-54 dependent transcriptional regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 468 PF00072: Response_reg" amino acids 4 to 111 (108 residues), 85.8 bits, see alignment E=7.1e-28 PF14532: Sigma54_activ_2" amino acids 142 to 312 (171 residues), 72.9 bits, see alignment E=9.8e-24 PF00158: Sigma54_activat" amino acids 142 to 307 (166 residues), 236.6 bits, see alignment E=3.9e-74 PF07728: AAA_5" amino acids 165 to 293 (129 residues), 37.2 bits, see alignment E=8.8e-13 PF02954: HTH_8" amino acids 404 to 444 (41 residues), 51.8 bits, see alignment 1.7e-17

Best Hits

Swiss-Prot: 41% identical to PILR_PSEAE: Type 4 fimbriae expression regulatory protein PilR (pilR) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: None (inferred from 95% identity to rpf:Rpic12D_3878)

Predicted SEED Role

"Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (468 amino acids)

>ABZR87_RS23515 sigma-54 dependent transcriptional regulator (Ralstonia sp. UNC404CL21Col)
MPHILIVEDDANARAALGELVGAEGFTTALAGSLRDARIQMSRHSPDAVLIDLVLPDGNG
MDLMEDIAPHSGTEIIVMTGHASVETAVEALRMGAADYLVKPVNFQRLKSVLARIPRPGD
LKAEIGNLRGELRRLGLFGQMLGNSTAMQTLYDQVSRVAPTEATVLLIGESGTGKELAAQ
TIHDLSLRRKQPFLPVNCGAISPNLIESEMFGHERGSFTGADRQHKGYFERANGGTLFLD
EITEMPIELQVKLLRVLETGVFMRVGTNREIDSDVRVIAATNRDPEEAVADGKLRADLYH
RLNVFPLQLPPLRERGKDVELLAQHFLDQLNAQSNTKKAFLPPAMETLRSYHWPGNVREL
RNYVQRAYILSDDAGIDTANVPLQVSSTQTTSGSTLTISVGTSLASADKKLILATLEQCG
GVKKRAAELLGISLKTLYNRLEEYGNSGGEDGGEGNSAGSGRAHATEA