Protein Info for ABZR87_RS23230 in Ralstonia sp. UNC404CL21Col

Annotation: NAD(P)-dependent oxidoreductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01370: Epimerase
  • amino acids 10 to 185 (176 residues), 75.1 bits, E=1.8e-24
• PF01073: 3Beta_HSD
  • amino acids 11 to 200 (190 residues), 38.3 bits, E=2.4e-13
• PF16363: GDP_Man_Dehyd
  • amino acids 11 to 135 (125 residues), 32.9 bits, E=1.5e-11
• PF13460: NAD_binding_10
  • amino acids 14 to 134 (121 residues), 34.3 bits, E=6.7e-12
• PF07993: NAD_binding_4
  • amino acids 51 to 184 (134 residues), 29 bits, E=1.8e-10

Best Hits

KEGG orthology group: None (inferred from 86% identity to rso:RS02194)

Predicted SEED Role

"UDP-glucose 4-epimerase (EC 5.1.3.2)" in subsystem Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway or Lactose and Galactose Uptake and Utilization or N-linked Glycosylation in Bacteria or Rhamnose containing glycans or linker unit-arabinogalactan synthesis (EC 5.1.3.2)

MetaCyc Pathways

• UDP-α-D-galactose biosynthesis (1/1 steps found)
• UDP-N-acetyl-D-galactosamine biosynthesis I (1/1 steps found)
• superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis (4/6 steps found)
• UDP-α-D-galactofuranose biosynthesis (1/2 steps found)
• D-galactose degradation I (Leloir pathway) (3/5 steps found)
• colanic acid building blocks biosynthesis (7/11 steps found)
• UDP-N-acetyl-D-galactosamine biosynthesis II (4/7 steps found)
• D-galactose detoxification (1/3 steps found)
• stachyose degradation (2/7 steps found)
• UDP-sugars interconversion (3/9 steps found)
• teichuronic acid biosynthesis (B. subtilis 168) (2/9 steps found)
• superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (12/33 steps found)
• mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (1/18 steps found)

KEGG Metabolic Maps

• Galactose metabolism
• Nucleotide sugars metabolism

Isozymes

Compare fitness of predicted isozymes for: 5.1.3.2

Use Curated BLAST to search for 5.1.3.2

Protein Sequence (308 amino acids)

>ABZR87_RS23230 NAD(P)-dependent oxidoreductase (Ralstonia sp. UNC404CL21Col)
MADYQTPARVLVTGVAGNLGRKVVEALASAPWCTSIIGVDWVAQNVEFSPQAAARFQWVK
ADLTQADGAWTDLLGNVDAVIHLAAIHSTPDATWEQALASYGMTLNVLQAAATHGVRRFV
FASSNHAMGAYKDQPLAGTIGPGKLTAELAPAPGTRWNNGTEDVYSLAYGTSKAMGERLC
KAVGAVSAANGGKLSIVSLRIGWALPDDNDPNDINYSGTADTPVPTELPDEASRVALRWF
RNMWLSNGDLRQLFLCSVTADPARWPAPAIVVNGVSNNRGMDWGLETGRELLGYEPQDDL
YALIRQPA