Protein Info for ABZR87_RS22845 in Ralstonia sp. UNC404CL21Col

Annotation: alpha,alpha-trehalase TreA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 537 signal peptide" amino acids 1 to 32 (32 residues), see Phobius details PF01204: Trehalase" amino acids 59 to 534 (476 residues), 554.4 bits, see alignment E=1.5e-170

Best Hits

Swiss-Prot: 82% identical to TREA_RALSO: Periplasmic trehalase (treA) from Ralstonia solanacearum (strain GMI1000)

KEGG orthology group: K01194, alpha,alpha-trehalase [EC: 3.2.1.28] (inferred from 84% identity to rsl:RPSI07_mp0256)

MetaCyc: 60% identical to periplasmic trehalase (Escherichia coli K-12 substr. MG1655)
Alpha,alpha-trehalase. [EC: 3.2.1.28]

Predicted SEED Role

"Trehalase (EC 3.2.1.28); Periplasmic trehalase precursor (EC 3.2.1.28)" (EC 3.2.1.28)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.2.1.28

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (537 amino acids)

>ABZR87_RS22845 alpha,alpha-trehalase TreA (Ralstonia sp. UNC404CL21Col)
MHRQAHFLIRRRVANVAAWLAFGLAASSALADVGVGAALPPSPDKLYGDLFVAVQTAQVY
PDQKTFVDAVPKAAPAVILQAYQAQKNVPGFSLKAFVDQYFTPPVDTPVTPPAGQSLRAH
INWLWPALTRTTTTASDNSSLIPLPKPYVVPGGRFREGYYWDTYFTMLGLQEAGREDLVD
NMLDNFAYAIDQFGHIPNGNRTYYLSRSQPPFFALMVELAAQKEGDAALKRYLPQLRKEY
AYWMRGAATTPGGQASSNVVVMRDGTVLNRYWDDQDTPRPESYLQDVTTAQQTPARPANE
IWRDLRAAAESGWDFSSRWFGDNATLGTIRTTSIVPVDLNSLMFQLEKTIARGCTAARDF
ACTVEYSVRAGKRAVAIERYLWHPAGYYADYDWQLGRVRDNKSAAMTYPLFVGAARPDRA
WKTLQWTQQALLQVGGLSTTTFKTGQQWDAPNGWAPLQWIALRGAQRYGWQPLAQAIGER
FLGSVEQLYASQQKLVEKYIVDGTGSGGGGGEYPLQDGFGWTNGVTLKLLDAYGRGQ