Protein Info for ABZR87_RS22185 in Ralstonia sp. UNC404CL21Col

Annotation: EAL domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 578 PF00989: PAS" amino acids 1 to 102 (102 residues), 31.1 bits, see alignment E=5.3e-11 PF08448: PAS_4" amino acids 3 to 102 (100 residues), 38 bits, see alignment E=4.2e-13 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 139 to 300 (162 residues), 157.2 bits, see alignment E=1.6e-50 PF00990: GGDEF" amino acids 142 to 298 (157 residues), 174.4 bits, see alignment E=3.9e-55 PF00563: EAL" amino acids 320 to 553 (234 residues), 249 bits, see alignment E=1.1e-77

Best Hits

KEGG orthology group: None (inferred from 92% identity to rpi:Rpic_4752)

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (578 amino acids)

>ABZR87_RS22185 EAL domain-containing protein (Ralstonia sp. UNC404CL21Col)
MVNALTEGILVCGVDRRVTYANPSAARLLGLPVDALVGRLLPTVVTSAVDEFDASIHEAD
WPDQDVIAEGQPQLNQIFGMHCVDGRTVWVSSNWTPLYADGGHSMTATPRASEAGATPYS
VLVSLVDITQIREAQQRIRHLATHDTLTGLLNRSALEDRLEHALALARRNRSRVSVMFLD
LDRFKNVNDTLGHQFGDMLLREVAARLQACAREADTVARLGGDEFVVMLEALDGLGTRRV
AERILSAISAPFHIEGQELYLGVSIGIAVAPHDGDDPNTLLRKADAAMYLAKERGRNNFQ
TFTSDLDDRVSRRFRIESGLRRASDRNEFYADYQPRVDVRSGRIVSVEALIRWNSADFGR
MMPGQFIQDAEETGLIVEIDRWILRAACDQLARWRRIGLPDLRMSINLSGQAFSSGQLSG
MVRGALSTSGLPGNAVELEMTEGILIRDDPSLHALLTELRAMGVSLALDDFGTGYSSLSY
LHRFPIDTLKIDRSFVQDLPHVAERAAITRAIIMMAQAMGMKTVAEGVETTGQLEFLREV
GCDEFQGYLLTRPLEPAAVQDLVRENARRYGERVPRFL