Protein Info for ABZR87_RS21860 in Ralstonia sp. UNC404CL21Col
Annotation: beta-ketoacyl-ACP synthase III
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 59% identical to BEKAS_PSEAE: Beta-ketodecanoyl-[acyl-carrier-protein] synthase (PA3286) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
KEGG orthology group: K00648, 3-oxoacyl-[acyl-carrier-protein] synthase III [EC: 2.3.1.180] (inferred from 93% identity to rpf:Rpic12D_3635)MetaCyc: 59% identical to beta-ketodecanoyl-[acyl-carrier-protein] synthase (Pseudomonas aeruginosa PAO1)
RXN-13613 [EC: 2.3.1.207]
Predicted SEED Role
"3-oxoacyl-[acyl-carrier-protein] synthase, KASIII (EC 2.3.1.180)" (EC 2.3.1.180)
MetaCyc Pathways
- superpathway of fatty acids biosynthesis (E. coli) (50/53 steps found)
- superpathway of fatty acid biosynthesis II (plant) (38/43 steps found)
- superpathway of fatty acid biosynthesis I (E. coli) (14/16 steps found)
- fatty acid salvage (6/6 steps found)
- fatty acid biosynthesis initiation (type II) (3/3 steps found)
- superpathway of fatty acid biosynthesis initiation (4/5 steps found)
- streptorubin B biosynthesis (20/34 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 2.3.1.180
Use Curated BLAST to search for 2.3.1.180 or 2.3.1.207
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (373 amino acids)
>ABZR87_RS21860 beta-ketoacyl-ACP synthase III (Ralstonia sp. UNC404CL21Col) MHDVVISGTGLWVAPEVITNEELVASYNAYTQLYNAQHAAAIAAGELPALAESSAEFIEK ASGIRQRYVIDKAGVLDPMRMRPHLTPRPDDALSLQAEIGVAAARDALAAAGRDAADVDM LLCATSNFQRPYPALGVEIQNGIGAGGYAFDMNVACSSATFGLEQAINAVRSGTARAALV VSPEITSGHLDWKDRDCHFIFGDVCTAVLVERAEDTRSADAWRVLGTKCATSFSNNIRNN AGYLSRSEDRNPDDRDQLFRQEGRKVFKEVCPMAAEHIAGHLQQLGHAPADVRRFWLHQA NLAMNQLIGKRLLGHDASADEAPVILDEFANTASAGSIIAFHRHRADLKSGDLGMICSFG AGYSIGSVAVQKQ