Protein Info for ABZR87_RS21715 in Ralstonia sp. UNC404CL21Col

Annotation: TolC family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 389 PF02321: OEP" amino acids 15 to 189 (175 residues), 63.5 bits, see alignment E=1.2e-21 amino acids 218 to 388 (171 residues), 72.8 bits, see alignment E=1.6e-24

Best Hits

Swiss-Prot: 49% identical to CZCC_CUPMC: Cobalt-zinc-cadmium resistance protein CzcC (czcC) from Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34)

KEGG orthology group: None (inferred from 83% identity to rsl:RPSI07_mp0428)

Predicted SEED Role

"Heavy metal RND efflux outer membrane protein, CzcC family" in subsystem Cobalt-zinc-cadmium resistance

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (389 amino acids)

>ABZR87_RS21715 TolC family protein (Ralstonia sp. UNC404CL21Col)
MSGASVVAATERVTLQQAVERALQTHPALAAAGYEVAASEGALDQARRLRNPEAAFTTED
VRRDRATMTAQLNIPLELGGKRGARTRAAEVARDATTQDAAVLQAELRADVTRAFFDLVI
AQERLSLAQASDALAAQAESAAARRVQAGKVSPVEQTKAGVARASAAIELRDANAELRVA
QRALAAFWGTPSAAPEADGSAETLPAVPLEARQAAGTLENTPRAIRARLEIDRRQALANV
ERSKRVPDVTLTVGAKRDSAANNNMAVLGIAVPLPLFDRNQGSQLEAQRLADKAFEDYRA
LQLEQNATLAQDVARLDAARAAVQSLRQDVLPGAQRAYDAARIGFDAGKFNFLDVLDAQR
TLFQARAQYLAALSRAHQAAAGIDRILGR