Protein Info for ABZR87_RS21585 in Ralstonia sp. UNC404CL21Col

Annotation: multidrug efflux SMR transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 109 signal peptide" amino acids 1 to 21 (21 residues), see Phobius details transmembrane" amino acids 32 to 52 (21 residues), see Phobius details amino acids 61 to 82 (22 residues), see Phobius details amino acids 88 to 106 (19 residues), see Phobius details PF00893: Multi_Drug_Res" amino acids 5 to 96 (92 residues), 89.6 bits, see alignment E=7.7e-30

Best Hits

Swiss-Prot: 54% identical to GDX_YERPE: Guanidinium exporter (gdx) from Yersinia pestis

KEGG orthology group: K11741, quaternary ammonium compound-resistance protein SugE (inferred from 67% identity to axy:AXYL_06105)

MetaCyc: 48% identical to guanidinium exporter (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-368; TRANS-RXN-369

Predicted SEED Role

"Quaternary ammonium compound-resistance protein SugE"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (109 amino acids)

>ABZR87_RS21585 multidrug efflux SMR transporter (Ralstonia sp. UNC404CL21Col)
MLQTAWLWLLAAGAVEIAMAVSLKFAQGWTRPIPSVLGIVTALASVFLLTHAMRGLPAGT
AYAIWTGIGSVGVTVLGIVLFGESMQPARLACIGLVIAGTVGLNFFNAA