Protein Info for ABZR87_RS20560 in Ralstonia sp. UNC404CL21Col

Annotation: error-prone DNA polymerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1079 TIGR00594: DNA polymerase III, alpha subunit" amino acids 14 to 1024 (1011 residues), 510.5 bits, see alignment E=5.1e-157 PF02811: PHP" amino acids 15 to 115 (101 residues), 55.2 bits, see alignment E=2.9e-18 PF07733: DNA_pol3_alpha" amino acids 299 to 554 (256 residues), 292.1 bits, see alignment E=1.1e-90 PF17657: DNA_pol3_finger" amino acids 557 to 735 (179 residues), 171.2 bits, see alignment E=3.1e-54 PF14579: HHH_6" amino acids 811 to 908 (98 residues), 73.2 bits, see alignment E=4.2e-24 PF01336: tRNA_anti-codon" amino acids 992 to 1063 (72 residues), 30.5 bits, see alignment 6.9e-11

Best Hits

Swiss-Prot: 97% identical to DNAE2_RALPJ: Error-prone DNA polymerase (dnaE2) from Ralstonia pickettii (strain 12J)

Predicted SEED Role

"macromolecule metabolism; macromolecule synthesis, modification; dna - replication, repair, restr./modif."

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1079 amino acids)

>ABZR87_RS20560 error-prone DNA polymerase (Ralstonia sp. UNC404CL21Col)
MTSATPFPTLPAYAELHCISNFTFLTGASHPYELVERAKLYGYQALALTDECSVAGTARA
LVASKEYELKLIIGSRFTVRNADGEPWLRLVLLAQNIEGYGNLSEIITHARLAAPKGEYR
LLADDLAAPKGELAHLRGVPDCLAILLPDYDPDPQQLLAQAWWCQRVFGDRLSIALELPL
RHADDRHRGTVGAVSEQIDVPMVATSGVQMHTRQRKPLHDVLTAIRLSKPLSECGLELAP
SAEQAMRTRVQLSYLYQGERGKRILRRTVELAALCNFSLDEIQYEYPSEVVPEGMTPAEY
LHAETLAGAARRYPNGVSEKVREQIQEELGLIAELGYEPFFLTVYDVVKFARNEGILCQG
RGSAANSAVCYCLGITEVNPDSGNTLFARFLSRARNEPPDIDVDFEHQRREEVIQYIYKK
YGVTRTALAAALITYRTRSALRDVGRALGIDLGIIEQVAKGQAWWDSRKEFVQRAGQQGL
DPESPLVLRWAQLVDQLRGFPRHLSQHVGGFVIAQGKLSRLVPIENAAMENRRVIQWDKD
DLESLRLLKVDVLALGMLTAIRRTLDMVDALPGRREHYGATTKLAMQNLHDGDKKTYDMI
CRAETIGVFQIESRAQQSMLPRLRPREYYDLVIQVAIVRPGPIQGGMVHPYLQRREAKRN
GNTDCVTYPGPEVKAVLERTLGVPIFQEQVMEIAMKAGDFTPDDADRLRRDMAAWKRKGN
LTQHQERLVHAMVEKRGYDPAFVEALCKQMEGFAEYGFPESHAAGFAKLAYVSSFLKCHE
PAAFFAALLNSQPMGFYSPSQLVQEARRSHVRVLPADVTASVWDSTLHLRADGEVGENGL
VQPDIRLGLNRIRGMRKPAAERIEAARAQAPFTSVEDLAHRAALDRHDLNVLAAANALKS
LAGHRRQALWQTLALQEPGHDHALLRQARPVEAPLELPAPPIGEEVMADYGSLGLSLQSH
PLRLLRARLERMRFATAATLAGYRNGQLARACGIVTVRQRPGTANGTIFVSIEDETGAIN
VILWPHLIERQRREVLNAQLLGVYGKWQCERETRHLVAQHLVDLTPLLGRLATSSRDFH