Protein Info for ABZR87_RS20465 in Ralstonia sp. UNC404CL21Col

Annotation: phosphonoacetaldehyde hydrolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 292 TIGR01422: phosphonoacetaldehyde hydrolase" amino acids 26 to 277 (252 residues), 353 bits, see alignment E=8.1e-110 PF00702: Hydrolase" amino acids 27 to 218 (192 residues), 52.9 bits, see alignment E=6.7e-18 PF13419: HAD_2" amino acids 46 to 223 (178 residues), 25.5 bits, see alignment E=1.4e-09 TIGR01509: HAD hydrolase, family IA, variant 3" amino acids 102 to 223 (122 residues), 32.7 bits, see alignment E=8e-12

Best Hits

Swiss-Prot: 71% identical to PHNX_PSEE4: Phosphonoacetaldehyde hydrolase (phnX) from Pseudomonas entomophila (strain L48)

KEGG orthology group: K05306, phosphonoacetaldehyde hydrolase [EC: 3.11.1.1] (inferred from 97% identity to rpi:Rpic_4474)

MetaCyc: 71% identical to phosphonoacetaldehyde hydrolase subunit (Pseudomonas aeruginosa)
Phosphonoacetaldehyde hydrolase. [EC: 3.11.1.1]

Predicted SEED Role

"Phosphonoacetaldehyde hydrolase (EC 3.11.1.1)" in subsystem Phosphonate metabolism (EC 3.11.1.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.11.1.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (292 amino acids)

>ABZR87_RS20465 phosphonoacetaldehyde hydrolase (Ralstonia sp. UNC404CL21Col)
MGDSSPITARQAGADRLNPGSTPLRLEAAVLDWAGTVVDFGSFAPTQIFVEAFAEFGVAI
TLDEARGPMGLGKWDHIRTLCNDGAIAARFSLAHGRMPTDDDVTAIYNRFMPLQIEKVAA
HSALIPGALDTVAALREAGLKIGTCSGYPRVVMDRVVDLAAKAGYTPDCVVACDEVPRAR
PWPAQALRCVVDLAIGDVAACVKVDDTVPGIEEGRRAGMWTVALLMSGNALGLPYAEYAA
LSADERARHRVAISAGFAACRPHYEIDTIADLPEVVADINRRLARGERPQCI